Efficacy Enhancement Services

Introduction

Biopharmaceutical programs often encounter challenges such as low therapeutic indices, off-target effects, emerging resistance, and suboptimal delivery efficiency. Our OncoVirapy™ Platform addresses these hurdles through advanced viral engineering, precision gene editing, and sophisticated immunomodulation strategies, improving therapeutic outcomes, reducing side effects, and overcoming resistance. Meticulously designed to elevate the potential of biological agents, particularly in advanced gene and viral therapies, our comprehensive solutions tackle bottlenecks in efficacy, specificity, and safety. From optimizing gene delivery vehicles to engineering cutting-edge immunotherapeutic approaches, we ensure your projects achieve their full therapeutic promise.

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Enhancing Efficacy

Fig.1 The anti-tumor mechanism of adenovirus.¹

Improving the therapeutic effect is the key to the development of biopharmaceuticals. At Creative Biolabs, we are focused on leveraging genomic engineering to improve the potency, specificity, and safety of gene delivery or cancer therapy by incorporating adenoviral antitumor mechanisms.

The core of our service lies in strategically modifying therapeutic vectors, especially oncolytic adenoviruses, to maximize their impact while minimizing side effects. This involves a multifaceted approach:

• Enzyme/Prodrug Activated Oncolytic Adenovirus: Express enzymes (e.g., cytosine deaminase) to convert prodrugs into cytotoxins within tumors, enhancing localized cell-killing while minimizing systemic toxicity via dual viral-drug action.
• Immunomodulatory Cytokine Oncolytic Adenovirus: Arm viruses with cytokines (e.g., GM-CSF, IL-12) to reshape the tumor microenvironment, recruiting immune cells and transforming "cold" tumors into immunogenic "hot" tumors.
• Immune Checkpoint Blockade of Oncolytic Adenovirus: Express antagonists (e.g., anti-PD-L1) to counteract immune suppression, combining oncolysis with immune potentiation to evade tumor escape mechanisms.
• Tumor Microenvironment Regulates Oncolytic Adenovirus: Design viruses triggered by tumor-specific elements (hypoxia, proteases) to ensure selective replication in hostile environments, sparing healthy tissues.
• Tumor-Targeting Antigen/Receptor-like Oncolytic Adenovirus: Modify capsid proteins to bind tumor-associated antigens (e.g., EGFR, FRα), enhancing specificity and minimizing off-target effects.
• Other Functional Molecules Resemble Oncolytic Adenovirus: Incorporate pro-apoptotic genes, anti-angiogenic factors, or matrix-degrading enzymes to synergistically inhibit growth, metastasis, and recurrence.
• Targeted Gene Disruption Oncolytic Adenovirus: Use gene editing methods to deliver components that knockout genes critical for tumor survival or immune evasion, sensitizing cells to viral and immune attack.

Tab.1 Common oncolytic adenoviruses loaded with functional molecules.

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What we can offer

At Creative Biolabs, our Enhancing Efficacy service is designed to be your strategic partner in advancing cutting-edge biological therapies. We offer a comprehensive suite of capabilities, ensuring that your projects benefit from the highest standards of scientific rigor and operational excellence. Our approach is highly customizable, and tailored to meet the unique demands of each therapeutic candidate and research objective.

• Customized Vector Engineering: We provide bespoke design and engineering of adenoviral vectors and other platforms, optimizing for specific therapeutic payloads, tissue tropism, and desired expression profiles. Our expertise covers precise genomic modifications for enhanced tumor selectivity and reduced off-target effects.
• Integrated Efficacy Enhancement Strategies: From enzyme/prodrug activation and immunomodulatory cytokine incorporation to immune checkpoint blockade and tumor microenvironment regulation, we offer a full spectrum of strategies to maximize therapeutic potency and minimize resistance.
• Advanced Gene Editing Integration: Leveraging our deep understanding of gene editing technologies and their delivery via adenoviral vectors, we facilitate targeted gene disruption within cells, enabling precise therapeutic interventions and overcoming critical biological hurdles.
• Robust Preclinical Development Support: Our services extend to rigorous in vitro and in vivo validation, providing comprehensive data on biodistribution, therapeutic response, and safety, crucial for successful progression through preclinical and clinical stages.
• Flexible Development Scales: Whether your project requires early-stage proof-of-concept studies or scaled-up vector production for preclinical validation, Creative Biolabs adapts to your needs, ensuring a seamless transition across different development phases.
• Expert Consultation and Project Management: Beyond technical execution, we offer unparalleled scientific consultation and dedicated project management, guiding you through complex challenges and ensuring transparent communication and timely delivery of results.

Why Choose Us?

Creative Biolabs is a leader in advanced biological engineering, offering unparalleled expertise and a proven track record in enhancing therapeutic efficacy. Our deep understanding of viral vector biology, particularly adenoviruses, combined with cutting-edge gene editing and immunomodulation capabilities, sets us apart. We prioritize precision, scalability, and robust scientific rigor in every project, ensuring your therapeutic innovations reach their full potential.

At Creative Biolabs, our service provides comprehensive solutions for developing potent and precise therapeutic agents through cutting-edge viral engineering and strategic immunomodulation. We empower our clients to overcome critical challenges in drug development, leading to more effective and safer therapies.

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Reference

1. Zhao, Yaqi, et al. "Oncolytic adenovirus: prospects for cancer immunotherapy." Frontiers in microbiology 12 (2021): 707290. DOI: 10.3389/fmicb.2021.707290. Distributed under Open Access license CC BY 4.0, without modification.

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