Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
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Loading...All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
CD48 molecule is a glycosylphosphatidylinositol-anchored immunoglobulin superfamily ligand encoded by CD48 gene, broadly expressed across hematopoietic immune cell subsets, localized exclusively to outer plasma membrane lipid bilayers. Distinct from other GPI-linked immune surface molecules, CD48 relies on conserved extracellular immunoglobulin domains to engage NK cell surface SLAM family receptors, while simultaneously delivering secondary co-stimulatory signals to amplify cytotoxic lymphocyte effector cascades. Under resting physiological immune states, basal CD48 surface expression sustains low-level interimmune cell recognition without triggering excessive cytotoxic activation. Upon pathogen exposure and immune cell conjugation, accumulated CD48-receptor binding complexes stabilize cell-cell junctions, facilitating downstream cytotoxic cytokine secretion and target cell clearance programs. Unlike broad-spectrum adhesion molecules with general cell anchoring roles, CD48 bears specialized NK cell co-stimulatory functions that cannot be fully compensated by other surface glycoproteins, linking intercellular ligand-receptor ligation directly to innate cytotoxic immune pathways. Loss of functional CD48 severely blunts NK cell-mediated anti-pathogen and anti-tumor responses and weakens systemic innate immune surveillance capacity, while sustained abundant CD48 expression amplifies cytotoxic inflammatory signaling, establishing CD48 as a core research target for GPI-anchored immune glycoprotein biology and immunostimulatory compound screening.
CD48 executes core receptor-binding co-stimulatory function anchored to cell surface lipid bilayers, utilizing conserved extracellular Ig-like domains to power high-affinity recognition of NK cell SLAM receptors. Conserved ligand-binding pockets exclusively recognize lymphoid SLAM receptor ectodomains, separating its ligand spectrum from non-specific adhesion receptors distributed across tissue cell surfaces. CD48-mediated receptor crosslinking bridges immune cell contact and cytotoxic signal transduction, balancing intercellular adhesion stability and innate cytotoxic response intensity according to antigen exposure levels. CD48 participates in extensive physiological processes including NK cell priming, hematopoietic cell crosstalk and tumor immune surveillance. Deficient CD48 surface expression disrupts lymphocyte cross-recognition and impairs innate anti-tumor immune defense. Therefore, CD48 represents a pivotal research target for GPI-linked immunoglobulin superfamily study and immune activator compound screening.
Fig. 1 Integrated multi-layer mechanistic overview: pathogenic CD48 mutations impair endoplasmic reticulum GPI-anchored protein trafficking to the plasma membrane, triggering recurrent autoinflammatory phenotypes, dysfunctional adaptive antiviral immunity and sustained inflammatory progression in human carriers and knockout murine models.1
The biological functions of CD48 are focused on SLAM receptor recognition, interimmune cell adhesion and cytotoxic signal control:
Creative Biolabs offers high-quality CD48 proteins through optimized expression systems, including full-length GPI-anchored glycoprotein and isolated extracellular ligand-binding domain variants. These products retain native conformational characteristics and SLAM receptor binding biological activity, suitable for surface receptor interaction assays and immune stimulator screening. All CD48 proteins undergo strict quality control to ensure consistent performance and reliable application across diverse research platforms.
Not finding the membrane protein product you need? Contact us to start your one-stop custom service!
Creative Biolabs provides custom-engineered CD48 stable cell lines, including overexpression and blank control models. These cell lines are optimized for GPI-anchored ligand expression profiling and NK cell co-stimulatory signal functional analysis. Each cell line undergoes stringent validation to ensure stable expression profiles and consistent functional performance in diverse experimental contexts.
Not finding the stable cell line product you need? Contact us to start your one-stop custom service!
High-specificity recombinant antibodies targeting CD48 are developed via advanced antibody engineering technologies, with no cross-reactivity with other immunoglobulin superfamily GPI-anchored glycoproteins. These antibodies are validated for plasma membrane subcellular localization detection and hematopoietic tissue expression profiling, and can be combined with SLAM receptor detection reagents to analyze complete CD48 immune synapse complexes in primary lymphocyte models.
Not finding the recombinant antibody product you need? Contact us to start your one-stop custom service!
Beyond catalog products, Creative Biolabs offers specialized custom services for CD48 research:
CD48 is a GPI-anchored immune glycoprotein that binds NK cell SLAM receptors to deliver co-stimulatory signals and boost innate cytotoxic immunity.
CD48 acts as a critical link between hematopoietic cell adhesion and NK cell effector activation, governing host anti-tumor and anti-pathogen innate immune responses.
No, all CD48 products and services are strictly for research use only, not intended for clinical diagnosis or treatment.
Offerings include full-length CD48 GPI-anchored glycoproteins, isoform-specific detection antibodies and custom stable cell lines for NK cell immune research.
CD48 proteins are validated via SLAM receptor ligand-binding functional testing.
