Close
Close
Loading...
CONTACT US
:
:
:
Call us at:
:
:
:
Fax:
Email:

CDCP1

Products

Loading...

All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.

Background

CUB domain-containing protein 1 (CDCP1), encoded by the CDCP1 gene on chromosome 1p34.2 and also known as CD318 or Trask, is a glycosylated type I transmembrane protein. The deduced 836-amino-acid protein contains an N-terminal signal peptide, three extracellular CUB domains (C1r/C1s, Uegf, Bmp1)—protein interaction modules commonly found in proteins involved in development and cell adhesion—a single transmembrane region, and a cytoplasmic tail. The mature protein contains two CUB domains, a consensus type-1 palmitoylation motif, and five PxxP motifs that mediate binding to Src homology-3 (SH3) domains. CDCP1 is expressed in various tissues and cell types, including fibroblasts, and has been detected in hematopoietic stem cell subsets. The extracellular CUB domains participate in protein-protein interactions relevant to cell communication and adhesion, whereas the intracellular domain serves as a substrate for Src family kinases.

CDCP1 acts as a tyrosine phosphorylation-dependent signaling platform that converts extracellular signals into intracellular responses. Upon phosphorylation by Src family kinases at specific tyrosine residues in its cytoplasmic domain, CDCP1 recruits and activates downstream effectors such as protein kinase C delta (PKCδ). This CDCP1–PKCδ signaling axis has been reported to inhibit autophagy, contributing to anoikis resistance in certain cellular contexts. CDCP1 also associates with tetraspanin-enriched microdomains (TEMs) and interacts with tetraspanins like CD9; its phosphorylation status changes in response to dissociation of integrin α6β4 from laminin-5. These features make CDCP1 a valuable research target for studies of cell adhesion dynamics, Src family kinase signaling, tetraspanin web organization, and the molecular basis of anchorage-independent survival and cell migration.

Fig. 1 CDCP1 promotes cancer cell proliferation (generally under non-adherent conditions), survival and migration, and mediates resistance to chemo- and targeted-therapies. (OA Literature) Fig. 1 CDCP1 promotes cancer cell proliferation (generally under non-adherent conditions), survival and migration, and mediates resistance to chemo- and targeted-therapies.1

CDCP1 Protein Function: Roles in Src Family Kinase Signaling, Cell Adhesion, and Migration

CDCP1, encoded by the CDCP1 gene, functions as a transmembrane signaling molecule that integrates Src family kinase-dependent signaling with cell adhesion dynamics:

  • Src Family Kinase Substrate: CDCP1 contains five PxxP motifs in its cytoplasmic domain that mediate binding to Src homology-3 (SH3) domains, serving as a substrate for Src family kinases.
  • PKCδ Signaling Activation: Tyrosine phosphorylation of CDCP1 by SFKs recruits and activates protein kinase C delta (PKCδ), triggering downstream signaling cascades.
  • Tetraspanin Web Association: CDCP1 belongs to the tetraspanin web and has been reported to associate with tetraspanin-enriched microdomains (TEMs) and interact with tetraspanin proteins such as CD9.
  • Cell Adhesion and Migration: CDCP1 participates in the regulation of cell adhesion and motility, with its phosphorylation status responding to changes in integrin-mediated adhesion.
  • Anoikis Resistance and Cell Survival: Through downstream signaling involving PKCδ and other effectors, CDCP1 has been implicated in the regulation of anoikis resistance—the ability of cells to survive detachment from the extracellular matrix.

CDCP1 Membrane Protein Product

Creative Biolabs offers high-quality CDCP1 membrane protein products produced using optimized expression systems. These include full-length type I transmembrane protein that retains the native membrane-spanning domain and cytoplasmic tail, as well as isolated extracellular domain variants containing the CUB domains. The extracellular CUB domains mediate protein-protein interactions involved in cell adhesion and communication, making these proteins suitable for studies of CDCP1 interaction networks, tetraspanin web assembly, and adhesion-related signaling. All CDCP1 proteins undergo strict quality control to support consistent performance across applicable research platforms.

Custom CDCP1 Protein Product

Not finding the protein product you need? Contact us to start your one-stop custom service!

CDCP1 Stable Cell Line Product

Creative Biolabs provides custom-engineered CDCP1 stable cell lines, including overexpression and knockdown models. These cell lines are optimized for studies of Src family kinase signaling, cell adhesion dynamics, tetraspanin web organization, and anchorage-independent survival mechanisms. Each cell line undergoes stringent validation to ensure stable expression profiles and consistent functional performance in diverse experimental contexts.

CDCP1 Stable Cell Line Product

Not finding the stable cell line product you need? Contact us to start your one-stop custom service!

CDCP1 Recombinant Antibody Product

High-specificity recombinant antibodies targeting CDCP1 are developed using antibody engineering technologies for research applications involving CDCP1 expression, localization, and protein-protein interaction studies. These antibodies can be used in studies of CDCP1 distribution in relevant cell and tissue models and may also support characterization of CDCP1-containing tetraspanin complexes and signaling assemblies in combination with appropriate detection reagents.

CDCP1 Recombinant Antibody Product

Not finding the recombinant antibody product you need? Contact us to start your one-stop custom service!

Product Features

  • Native CUB Domain Structure Preservation: Maintains the characteristic extracellular CUB domain conformation essential for protein-protein interaction and adhesion studies.
  • Src Signaling Research Compatibility: Optimized reagent series for studies of Src family kinase signaling, PKCδ activation, and downstream phosphorylation-dependent pathways.
  • High Specificity for CDCP1: Minimizes non-specific cross-reactivity with other CUB domain-containing proteins and related transmembrane molecules.
  • Comprehensive Customization Support: Facilitates end-to-end development of customized proteins, antibodies and stable cell lines to address cell adhesion, migration, and signaling research demands.

Custom CDCP1 Research Services

Beyond catalog products, Creative Biolabs offers specialized custom services for CDCP1 research:

  • Custom CDCP1 Protein Production: Tailored expression of mutant and tagged CDCP1 constructs for protein-protein interaction and adhesion studies.
  • Custom Antibody Development: Generation of CDCP1-specific antibodies for immunostaining, flow cytometry, and protein detection applications.
  • Stable Cell Line Engineering: Construction of CDCP1-modified cell models for Src signaling, adhesion, and migration research.
  • Functional Assay Development: Custom design of cell adhesion, migration, and signaling pathway detection workflows.

Frequently Asked Questions (FAQs)

  1. What is the primary function of CDCP1?

    CDCP1 is a type I transmembrane protein that serves as a substrate for Src family kinases, participates in tetraspanin-enriched microdomains, and regulates cell adhesion, migration, and anchorage-independent survival through SFK-PKCδ signaling.

  2. Why is CDCP1 a significant research target?

    CDCP1 functions as a signaling hub that integrates Src family kinase-dependent phosphorylation with cell adhesion dynamics, making it a valuable target for studies of cell migration, adhesion regulation, and signaling pathway crosstalk.

  3. Are Creative Biolabs' CDCP1 products suitable for clinical use?

    No, all CDCP1 products and services are strictly for research use only, not intended for clinical diagnosis or treatment.

  4. What types of CDCP1 products does Creative Biolabs offer?

    Offerings include full-length CDCP1 transmembrane proteins, CUB domain-containing variants, specific detection antibodies, and custom stable cell lines for adhesion and signaling research.

  5. How are CDCP1 proteins validated for activity?

    CDCP1 proteins are validated via protein-protein interaction assays, phosphorylation-dependent signaling assays, and relevant functional characterization in applicable research platforms.

Reference
  1. He, Yaowu, et al. "New Crossroads for Potential Therapeutic Intervention in Cancer - Intersections Between CDCP1, EGFR Family Members and Downstream Signaling Pathways." Oncoscience 3.1 (2016): 5-8. Under Open Access license https://creativecommons.org/licenses/by/2.5/, without modification. https://doi.org/10.18632/oncoscience.286
Our customer service representatives are available 24 hours a day, 7 days a week. Contact Us
© 2026 Creative Biolabs. | Contact Us
;