Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
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Loading...All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
Solute carrier family 32 member 1 (SLC32A1, VGAT) is a synaptic vesicle integral transporter encoded by the SLC32A1 gene, belonging to SLC solute carrier superfamily and acting as the exclusive vesicular transporter for GABA and glycine inhibitory transmitters. SLC32A1 localizes exclusively to presynaptic inhibitory neuron vesicle membranes, carrying evolutionarily conserved 10-transmembrane solute carrier folds and proton-coupled transport motifs across species, serving as an essential modulator for cytoplasmic GABA uptake into synaptic vesicle lumens. Apart from central neural circuit balance, SLC32A1 also participates in peripheral inhibitory nerve signal transmission and modulates pain regulatory neural pathways; sustained decline of its functional expression will break excitation-inhibition balance in both central and peripheral nervous tissues and heighten neuronal hyperexcitability risk. SLC32A1-mediated proton-gradient dependent GABA transport exerts decisive effects on loading neurotransmitter stores for inhibitory synaptic transmission under physiological neural circuit conditions. Furthermore, SLC32A1 coordinates balanced excitatory-inhibitory neural network signaling. Distinct from monoamine vesicular transporters, SLC32A1 exhibits strict substrate selectivity for GABA and glycine inhibitory transmitters.
SLC32A1 executes biological functions via utilizing intravesicular proton electrochemical gradients to drive antiport uptake of cytoplasmic GABA molecules into secretory synaptic vesicles, generating high-concentration neurotransmitter pools ready for activity-dependent release. Its conserved transmembrane translocation domains mediate substrate recognition and proton counter-transport to maintain vesicular GABA storage capacity. SLC32A1 participates in inhibitory synapse maturation and central nervous system circuit balance. Reduced SLC32A1 abundance diminishes inhibitory synaptic output and elevates neuronal hyperexcitability risk. Therefore, SLC32A1 constitutes a pivotal research target for GABAergic synaptic physiology and epileptic disorder mechanisms.
Fig. 1 Full GABAergic synaptic transmission cycle, with SLC32A1 (VGAT) mediating vesicular GABA loading in presynaptic terminals.1
The biological functions of SLC32A1 are focused on proton-coupled antiport transport of inhibitory neurotransmitters into synaptic vesicles:
Creative Biolabs offers high-quality SLC32A1 proteins produced through optimized expression systems, including full-length SLC32A1 and selected transmembrane-domain constructs. Full-length SLC32A1 supports studies of proton-dependent vesicular GABA/glycine transport, while isolated domain constructs are intended for antigen, structural, or binding studies. Transport activity is evaluated only in appropriate full-length protein reconstitution or cell-based systems. All products undergo purity and applicable functional quality control.
Not finding the membrane protein product you need? Contact us to start your one-stop custom service!
Creative Biolabs provides custom engineered SLC32A1 stable cell lines, including overexpression and gene silencing models. These cell lines are optimized for vesicular neurotransmitter transport and GABAergic neuron research. Strict clonal screening removes unstable cell subpopulations, with full expression monitoring records provided for each cell batch to support long-term culture experiments. Each cell line undergoes strict validation procedures to ensure steady target expression levels and uniform functional performance across multiple experimental scenarios.
Not finding the stable cell line product you need? Contact us to start your one-stop custom service!
High-specificity recombinant antibodies targeting SLC32A1 are developed with advanced antibody engineering workflows, without cross-reactivity against other vesicular solute carriers. These antibodies pass multi-dimensional functional tests for synaptic vesicle staining and co-localization detection, formulated without harsh preservatives to fit nervous tissue section staining protocols. Pre-screening excludes cross-binding signals against other SLC family transporters.
Not finding the recombinant antibody product you need? Contact us to start your one-stop custom service!
Beyond catalog products, Creative Biolabs offers specialized custom services for SLC32A1 research:
SLC32A1 is a vesicular solute carrier that uses proton gradients to transport GABA into presynaptic vesicles for inhibitory neurotransmission.
SLC32A1 is required for all inhibitory synaptic signaling; reduced expression elevates neuronal hyperexcitability and seizure risk, establishing it as a vital research target.
No, all SLC32A1 products and services are strictly for research use only, not intended for clinical diagnosis or treatment.
Offerings include SLC32A1 proteins, high-specificity recombinant antibodies and custom stable cell lines for GABAergic synaptic and neurological research.
SLC32A1 proteins undergo functional verification via proton-coupled GABA substrate uptake capacity evaluation.
