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DR5 Bispecific Antibodies
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CAT# Product Name Species Reactivity BsAb Type Target 1 Host Animal 1 Target 2 Host Animal 2 INQUIRY
BSDG-H320 Recombinant Human Anti-DR5 x Human Anti-FAP Bispecific Antibody (Fv-IgG) Human Fv-IgG DR5 Human FAP Human Inquiry
BSDG-H308 Recombinant Human Anti-CEA x Human Anti-DR5 Bispecific Antibody (Fv-IgG) Human Fv-IgG CEA Human DR5 Human Inquiry
BSDG-152 Recombinant Anti-DR5 x Anti-FAP Bispecific Antibody (Fv-IgG) Human Fv-IgG DR5 Mouse FAP Mouse Inquiry
BSDG-136 Recombinant Anti-CEA x Anti-DR5 Bispecific Antibody (Fv-IgG) Human Fv-IgG CEA Mouse DR5 Mouse Inquiry
BABFV-H320 Recombinant Human Anti-DR5 x Human Anti-FAP Bispecific Antibody (F(ab')2-scFv2) Human F(ab')2-scFv2 DR5 Human FAP Human Inquiry
BABFV-H308 Recombinant Human Anti-CEA x Human Anti-DR5 Bispecific Antibody (F(ab')2-scFv2) Human F(ab')2-scFv2 CEA Human DR5 Human Inquiry
BABFV-152 Recombinant Anti-DR5 x Anti-FAP Bispecific Antibody (F(ab')2-scFv2) Human F(ab')2-scFv2 DR5 Mouse FAP Mouse Inquiry
BABFV-136 Recombinant Anti-CEA x Anti-DR5 Bispecific Antibody (F(ab')2-scFv2) Human F(ab')2-scFv2 CEA Mouse DR5 Mouse Inquiry
FABVC-H320 Recombinant Human Anti-DR5 x Human Anti-FAP Bispecific Antibody (Fab-scFv-Fc) Human Fab-scFv/sdAb-Fc DR5 Human FAP Human Inquiry
FABVC-H308 Recombinant Human Anti-CEA x Human Anti-DR5 Bispecific Antibody (Fab-scFv-Fc) Human Fab-scFv/sdAb-Fc CEA Human DR5 Human Inquiry
FABVC-152 Recombinant Anti-DR5 x Anti-FAP Bispecific Antibody (Fab-scFv-Fc) Human Fab-scFv/sdAb-Fc DR5 Mouse FAP Mouse Inquiry
FABVC-136 Recombinant Anti-CEA x Anti-DR5 Bispecific Antibody (Fab-scFv-Fc) Human Fab-scFv/sdAb-Fc CEA Mouse DR5 Mouse Inquiry
SCDBC-H320 Recombinant Human Anti-DR5 x Human Anti-FAP Bispecific Antibody (scDiabody-CH3) Human scDiabody-CH3 DR5 Human FAP Human Inquiry
SCDBC-H308 Recombinant Human Anti-CEA x Human Anti-DR5 Bispecific Antibody (scDiabody-CH3) Human scDiabody-CH3 CEA Human DR5 Human Inquiry
SCDBC-152 Recombinant Anti-DR5 x Anti-FAP Bispecific Antibody (scDiabody-CH3) Human scDiabody-CH3 DR5 Mouse FAP Mouse Inquiry
SCDBC-136 Recombinant Anti-CEA x Anti-DR5 Bispecific Antibody (scDiabody-CH3) Human scDiabody-CH3 CEA Mouse DR5 Mouse Inquiry
BSDBC-H320 Recombinant Human Anti-DR5 x Human Anti-FAP Bispecific Antibody (Diabody-CH3) Human Diabody-CH3 DR5 Human FAP Human Inquiry
BSDBC-H308 Recombinant Human Anti-CEA x Human Anti-DR5 Bispecific Antibody (Diabody-CH3) Human Diabody-CH3 CEA Human DR5 Human Inquiry
BSDBC-152 Recombinant Anti-DR5 x Anti-FAP Bispecific Antibody (Diabody-CH3) Human Diabody-CH3 DR5 Mouse FAP Mouse Inquiry
BSDBC-136 Recombinant Anti-CEA x Anti-DR5 Bispecific Antibody (Diabody-CH3) Human Diabody-CH3 CEA Mouse DR5 Mouse Inquiry
SCDBF-H320 Recombinant Human Anti-DR5 x Human Anti-FAP Bispecific Antibody (scDiabody-Fc) Human scDiabody-Fc DR5 Human FAP Human Inquiry
SCDBF-H308 Recombinant Human Anti-CEA x Human Anti-DR5 Bispecific Antibody (scDiabody-Fc) Human scDiabody-Fc CEA Human DR5 Human Inquiry
SCDBF-152 Recombinant Anti-DR5 x Anti-FAP Bispecific Antibody (scDiabody-Fc) Human scDiabody-Fc DR5 Mouse FAP Mouse Inquiry
SCDBF-136 Recombinant Anti-CEA x Anti-DR5 Bispecific Antibody (scDiabody-Fc) Human scDiabody-Fc CEA Mouse DR5 Mouse Inquiry
BSFVF-H320 Recombinant Human Anti-DR5 x Human Anti-FAP Bispecific Antibody (Tandem scFv-Fc) Human Tandem scFv-Fc DR5 Human FAP Human Inquiry
BSFVF-H308 Recombinant Human Anti-CEA x Human Anti-DR5 Bispecific Antibody (Tandem scFv-Fc) Human Tandem scFv-Fc CEA Human DR5 Human Inquiry
BSFVF-152 Recombinant Anti-DR5 x Anti-FAP Bispecific Antibody (Tandem scFv-Fc) Human Tandem scFv-Fc DR5 Mouse FAP Mouse Inquiry
BSFVF-136 Recombinant Anti-CEA x Anti-DR5 Bispecific Antibody (Tandem scFv-Fc) Human Tandem scFv-Fc CEA Mouse DR5 Mouse Inquiry
BSDBF-H320 Recombinant Human Anti-DR5 x Human Anti-FAP Bispecific Antibody (Diabody-Fc) Human Diabody-Fc DR5 Human FAP Human Inquiry
BSDBF-H308 Recombinant Human Anti-CEA x Human Anti-DR5 Bispecific Antibody (Diabody-Fc) Human Diabody-Fc CEA Human DR5 Human Inquiry
BSDBF-152 Recombinant Anti-DR5 x Anti-FAP Bispecific Antibody (Diabody-Fc) Human Diabody-Fc DR5 Mouse FAP Mouse Inquiry
BSDBF-136 Recombinant Anti-CEA x Anti-DR5 Bispecific Antibody (Diabody-Fc) Human Diabody-Fc CEA Mouse DR5 Mouse Inquiry
BSTF-H320 Recombinant Human Anti-DR5 x Human Anti-FAP Bispecific Antibody (scFv-Fc-scFv) Human scFv-Fc-scFv DR5 Mouse FAP Mouse Inquiry
BSTF-H308 Recombinant Human Anti-CEA x Human Anti-DR5 Bispecific Antibody (scFv-Fc-scFv) Human scFv-Fc-scFv CEA Mouse DR5 Mouse Inquiry
BSTF-152 Recombinant Anti-DR5 x Anti-FAP Bispecific Antibody (scFv-Fc-scFv) Human scFv-Fc-scFv DR5 Mouse FAP Mouse Inquiry
BSTF-136 Recombinant Anti-CEA x Anti-DR5 Bispecific Antibody (scFv-Fc-scFv) Human scFv-Fc-scFv CEA Mouse DR5 Mouse Inquiry
BSCFV-H320 Recombinant Human Anti-DR5 x Human Anti-FAP Bispecific Antibody (scFv-Fc) Human scFv-Fc DR5 Mouse FAP Mouse Inquiry
BSCFV-H308 Recombinant Human Anti-CEA x Human Anti-DR5 Bispecific Antibody (scFv-Fc) Human scFv-Fc CEA Mouse DR5 Mouse Inquiry
BSCFV-152 Recombinant Anti-DR5 x Anti-FAP Bispecific Antibody (scFv-Fc) Human scFv-Fc DR5 Mouse FAP Mouse Inquiry
BSCFV-136 Recombinant Anti-CEA x Anti-DR5 Bispecific Antibody (scFv-Fc) Human scFv-Fc CEA Mouse DR5 Mouse Inquiry
MNAB-H320 Recombinant Human Anti-DR5 x Human Anti-FAP Bispecific Antibody (Miniantibody) Human Miniantibody DR5 Mouse FAP Mouse Inquiry
MNAB-H308 Recombinant Human Anti-CEA x Human Anti-DR5 Bispecific Antibody (Miniantibody) Human Miniantibody CEA Mouse DR5 Mouse Inquiry
MNAB-152 Recombinant Anti-DR5 x Anti-FAP Bispecific Antibody (Miniantibody) Human Miniantibody DR5 Mouse FAP Mouse Inquiry
MNAB-136 Recombinant Anti-CEA x Anti-DR5 Bispecific Antibody (Miniantibody) Human Miniantibody CEA Mouse DR5 Mouse Inquiry
BSFC-H320 Recombinant Human Anti-DR5 x Human Anti-FAP Bispecific Antibody (scFv-CH3) Human scFv-CH3 DR5 Mouse FAP Mouse Inquiry
BSFC-H308 Recombinant Human Anti-CEA x Human Anti-DR5 Bispecific Antibody (scFv-CH3) Human scFv-CH3 CEA Mouse DR5 Mouse Inquiry
BSFC-152 Recombinant Anti-DR5 x Anti-FAP Bispecific Antibody (scFv-CH3) Human scFv-CH3 DR5 Mouse FAP Mouse Inquiry
BSFC-136 Recombinant Anti-CEA x Anti-DR5 Bispecific Antibody (scFv-CH3) Human scFv-CH3 CEA Mouse DR5 Mouse Inquiry
BSCC-H320 Recombinant Human Anti-DR5 x Human Anti-FAP Bispecific Antibody (scFv-CH1/CL) Human scFv-CH1/CL DR5 Mouse FAP Mouse Inquiry
BSCC-H308 Recombinant Human Anti-CEA x Human Anti-DR5 Bispecific Antibody (scFv-CH1/CL) Human scFv-CH1/CL CEA Mouse DR5 Mouse Inquiry
BSCC-152 Recombinant Anti-DR5 x Anti-FAP Bispecific Antibody (scFv-CH1/CL) Human scFv-CH1/CL DR5 Mouse FAP Mouse Inquiry
BSCC-136 Recombinant Anti-CEA x Anti-DR5 Bispecific Antibody (scFv-CH1/CL) Human scFv-CH1/CL CEA Mouse DR5 Mouse Inquiry
BIBD-H320 Recombinant Human Anti-DR5 x Human Anti-FAP Bispecific Antibody (Bibody) Human Bibody DR5 Mouse FAP Mouse Inquiry
BIBD-H308 Recombinant Human Anti-CEA x Human Anti-DR5 Bispecific Antibody (Bibody) Human Bibody CEA Mouse DR5 Mouse Inquiry
BIBD-152 Recombinant Anti-DR5 x Anti-FAP Bispecific Antibody (Bibody) Human Bibody DR5 Mouse FAP Mouse Inquiry
BIBD-136 Recombinant Anti-CEA x Anti-DR5 Bispecific Antibody (Bibody) Human Bibody CEA Mouse DR5 Mouse Inquiry
FABFV-H320 Recombinant Human Anti-DR5 x Human Anti-FAP Bispecific Antibody (Fab-Fv) Human Fab-Fv DR5 Human FAP Human Inquiry
FABFV-H308 Recombinant Human Anti-CEA x Human Anti-DR5 Bispecific Antibody (Fab-Fv) Human Fab-Fv CEA Human DR5 Human Inquiry
FABFV-152 Recombinant Anti-DR5 x Anti-FAP Bispecific Antibody (Fab-Fv) Human Fab-Fv DR5 Mouse FAP Mouse Inquiry
FABFV-136 Recombinant Anti-CEA x Anti-DR5 Bispecific Antibody (Fab-Fv) Human Fab-Fv CEA Mouse DR5 Mouse Inquiry
MiniB-H320 Recombinant Human Anti-DR5 x Human Anti-FAP Bispecific Antibody (Minibody) Human Minibody DR5 Human FAP Human Inquiry
MiniB-H308 Recombinant Human Anti-CEA x Human Anti-DR5 Bispecific Antibody (Minibody) Human Minibody CEA Human DR5 Human Inquiry
MiniB-152 Recombinant Anti-DR5 x Anti-FAP Bispecific Antibody (Minibody) Human Minibody DR5 Mouse FAP Mouse Inquiry
MiniB-136 Recombinant Anti-CEA x Anti-DR5 Bispecific Antibody (Minibody) Human Minibody CEA Mouse DR5 Mouse Inquiry
SCDB-H318 Recombinant Human Anti-DR5 x Anti-FAP Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody DR5 Human FAP Human Inquiry
SCDB-H306 Recombinant Human Anti-CEA x Anti-DR5 Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody CEA Human DR5 Human Inquiry
FABIG-H318 Recombinant Human Anti-DR5 x Anti-FAP Bispecific Antibody (Fab-IgG) Human Fab-IgG DR5 Human FAP Human Inquiry
FABIG-H306 Recombinant Human Anti-CEA x Anti-DR5 Bispecific Antibody (Fab-IgG) Human Fab-IgG CEA Human DR5 Human Inquiry
TRIB-H320 Recombinant Human Anti-DR5 x Anti-FAP Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv DR5 Human FAP Human Inquiry
TRIB-H308 Recombinant Human Anti-CEA x Anti-DR5 Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv CEA Human DR5 Human Inquiry
BSIG-H318 Human Anti-DR5 x Anti-FAP Bispecific Antibody (IgG-IgG) Human IgG-IgG DR5 Human FAP Human Inquiry
BSIG-H306 Human Anti-CEA x Anti-DR5 Bispecific Antibody (IgG-IgG) Human IgG-IgG CEA Human DR5 Human Inquiry
CROSSAB-H318 Recombinant Human Anti-DR5 x Anti-FAP Bispecific Antibody (CrossMab) Human CrossMab DR5 Human FAP Human Inquiry
CROSSAB-H306 Recombinant Human Anti-CEA x Anti-DR5 Bispecific Antibody (CrossMab) Human CrossMab CEA Human DR5 Human Inquiry
IGFV-H318 Recombinant Human Anti-DR5 x Anti-FAP Bispecific Antibody (IgG-scFv) Human IgG-scFv DR5 Human FAP Human Inquiry
IGFV-H306 Recombinant Human Anti-CEA x Anti-DR5 Bispecific Antibody (IgG-scFv) Human IgG-scFv CEA Human DR5 Human Inquiry
BSDB-H318 Recombinant Human Anti-DR5 x Anti-FAP Bispecific Antibody (Diabody) Human Diabody DR5 Human FAP Human Inquiry
BSDB-H306 Recombinant Human Anti-CEA x Anti-DR5 Bispecific Antibody (Diabody) Human Diabody CEA Human DR5 Human Inquiry
BSFAB-H318 Recombinant Human Anti-DR5 x Anti-FAP Bispecific Antibody (Tandem Fab) Human Tandem Fab DR5 Human FAP Human Inquiry
BSFAB-H306 Recombinant Human Anti-CEA x Anti-DR5 Bispecific Antibody (Tandem Fab) Human Tandem Fab CEA Human DR5 Human Inquiry
BSFV-H317 Recombinant Human Anti-DR5 x Anti-FAP Bispecific Antibody (Tandem scFv) Human Tandem scFv DR5 Human FAP Human Inquiry
BSFV-H306 Recombinant Human Anti-CEA x Anti-DR5 Bispecific Antibody (Tandem scFv) Human Tandem scFv CEA Human DR5 Human Inquiry
SCDB-152 Recombinant Anti-DR5 x Anti-FAP Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody DR5 Mouse FAP Mouse Inquiry
SCDB-136 Recombinant Anti-CEA x Anti-DR5 Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody CEA Mouse DR5 Mouse Inquiry
FABIG-152 Recombinant Anti-DR5 x Anti-FAP Bispecific Antibody (Fab-IgG) Human Fab-IgG DR5 Mouse FAP Mouse Inquiry
FABIG-136 Recombinant Anti-CEA x Anti-DR5 Bispecific Antibody (Fab-IgG) Human Fab-IgG CEA Mouse DR5 Mouse Inquiry
TRIB-152 Recombinant Anti-DR5 x Anti-FAP Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv DR5 Mouse FAP Mouse Inquiry
TRIB-136 Recombinant Anti-CEA x Anti-DR5 Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv CEA Mouse DR5 Mouse Inquiry
BSIG-152 Anti-DR5 x Anti-FAP Bispecific Antibody (IgG-IgG) Human IgG-IgG DR5 Mouse FAP Mouse Inquiry
BSIG-136 Anti-CEA x Anti-DR5 Bispecific Antibody (IgG-IgG) Human IgG-IgG CEA Mouse DR5 Mouse Inquiry
CROSSAB-152 Recombinant Anti-DR5 x Anti-FAP Bispecific Antibody (CrossMab) Human CrossMab DR5 Mouse FAP Mouse Inquiry
CROSSAB-136 Recombinant Anti-CEA x Anti-DR5 Bispecific Antibody (CrossMab) Human CrossMab CEA Mouse DR5 Mouse Inquiry
IGFV-152 Recombinant Anti-DR5 x Anti-FAP Bispecific Antibody (IgG-scFv) Human IgG-scFv DR5 Mouse FAP Mouse Inquiry
IGFV-136 Recombinant Anti-CEA x Anti-DR5 Bispecific Antibody (IgG-scFv) Human IgG-scFv CEA Mouse DR5 Mouse Inquiry
BSDB-152 Recombinant Anti-DR5 x Anti-FAP Bispecific Antibody (Diabody) Human Diabody DR5 Mouse FAP Mouse Inquiry
BSDB-136 Recombinant Anti-CEA x Anti-DR5 Bispecific Antibody (Diabody) Human Diabody CEA Mouse DR5 Mouse Inquiry
BSFAB-152 Recombinant Anti-DR5 x Anti-FAP Bispecific Antibody (Tandem Fab) Human Tandem Fab DR5 Mouse FAP Mouse Inquiry
BSFAB-136 Recombinant Anti-CEA x Anti-DR5 Bispecific Antibody (Tandem Fab) Human Tandem Fab CEA Mouse DR5 Mouse Inquiry
BSFV-152 Recombinant Anti-DR5 x Anti-FAP Bispecific Antibody (Tandem scFv) Human Tandem scFv DR5 Mouse FAP Mouse Inquiry
BSFV-136 Recombinant Anti-CEA x Anti-DR5 Bispecific Antibody (Tandem scFv) Human Tandem scFv CEA Mouse DR5 Mouse Inquiry

Background

Fig.1 Death receptor 5 activation pathway. (Huang and Donald, 2009)Fig.1 Death receptor 5 activation pathway.1

Death receptor 5 (DR5) is a membrane receptor that plays a pivotal role in triggering apoptosis, or programmed cell death, in response to various stimuli, including the presence of damaged or infected cells. DR5 can initiate the extrinsic apoptotic pathway when bound by its ligand, such as TNF-related apoptosis-inducing ligand (TRAIL). Upon ligand binding, DR5 undergoes a conformational change, leading to the recruitment of intracellular adaptor proteins and the formation of a death-inducing signaling complex (DISC). This complex activates caspase enzymes that orchestrate the morphological and biochemical shifts correlated to apoptosis. DR5 has application fields in cancer therapy, as it represents a promising target for inducing apoptosis in cancer cells. Research efforts focus on developing agonistic antibodies or TRAIL-based therapeutics that selectively activate DR5 to eliminate malignant cells while sparing normal tissues.

Reference

  1. Huang, Zhi-Qiang, and Donald J Buchsbaum. “Monoclonal antibodies in the treatment of pancreatic cancer.” Immunotherapyvol. 1,2 (2009): 223-9.
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