Anti-AFF1 Aptamer SELEX Service(Cat#: CTApt-2468)

This is an aptamer development services to screening aptamers binds to the AFF1 with an affinity of 1nM~1μM.

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Summary
Specifications
Target Category Protein
Target AFF1
Alternative Names AF4/FMR2 Family Member 1; AF4; ALL1-Fused Gene From Chromosome 4 Protein; Pre-B-Cell Monocytic Leukemia Partner 1; Proto-Oncogene AF4; MLLT2; PBM1; Myeloid/Lymphoid Or Mixed-Lineage Leukemia (Trithorax (Drosophila) Homolog); Translocated To, 2; Myeloid/Lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila); Translocated To, 2; AF4/FMR2 Family, Member 1; Protein AF-4; Protein FEL; AFF1; AF-4; FEL
Gene ID 4299
UniProt ID P51825
Target Overview This gene encodes a member of the AF4/ lymphoid nuclear protein related to the Fragile X E syndrome (FRAXE) family of proteins, which have been implicated in human childhood lymphoblastic leukemia, fragile chromosome X intellectual disability, and ataxia. It is the prevalent mixed-lineage leukemia fusion gene associated with spontaneous acute lymphoblastic leukemia. Members of this family have three conserved domains: an N-terminal homology domain, an AF4/ lymphoid nuclear protein domain, and a C-terminal homology domain. The protein functions as a regulator of RNA polymerase II-mediated transcription through elongation and chromatin remodeling functions. Through RNA interference screens, this gene has been shown to promote the expression of CD133, a plasma membrane glycoprotein required for leukemia cell survival. Alternative splicing results in multiple transcript variants.
Chemical Modification N/A
Type DNA
Length 20-80 nt
Affinity (Kd) 1nM~1μM
Binding Conditions/Buffer PBS; buffer system with Serum; other
For Research Use Only. Not for Diagnostic or Therapeutic Applications.
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