Anti-AKAP13 Aptamer SELEX Service(Cat#: CTApt-2454)
This is an aptamer development services to screening aptamers binds to the AKAP13 with an affinity of 1nM~1μM.
Specific Inquiry 
Specifications
| Target Category |
Protein |
| Target |
AKAP13 |
| Alternative Names |
A-Kinase Anchoring Protein 13; Lymphoid Blast Crisis Oncogene; AKAP-Lbc; BRX; Breast Cancer Nuclear Receptor-Binding Auxiliary Protein; Non-Oncogenic Rho GTPase-Specific GTP Exchange Factor; Guanine Nucleotide Exchange Factor Lbc; Protein Kinase A-Anchoring Protein 13; Human Thyroid-Anchoring Protein 31; A Kinase (PRKA) Anchor Protein 13; A-Kinase Anchor Protein 13; LBC Oncogene; ARHGEF13; PROTO-LB; AKAP-13; PRKA13; C-Lbc; HA-3; Ht31; LBC; P47; PROTO-LBC; AKAP13; HT31 |
| Gene ID |
11214 |
| UniProt ID |
Q12802 |
| Target Overview |
The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms containing c-terminal dbl oncogene homology (DH) and pleckstrin homology (PH) domains. The DH domain is associated with guanine nucleotide exchange activation for the Rho/Rac family of small GTP binding proteins, resulting in the conversion of the inactive GTPase to the active form capable of transducing signals. The PH domain has multiple functions. Therefore, these isoforms function as scaffolding proteins to coordinate a Rho signaling pathway, function as protein kinase A-anchoring proteins and, in addition, enhance ligand-dependent activity of estrogen receptors alpha and beta. |
| Chemical Modification |
N/A |
| Type |
DNA |
| Length |
20-80 nt |
| Affinity (Kd) |
1nM~1μM |
| Binding Conditions/Buffer |
PBS; buffer system with Serum; other |
For Research Use Only. Not for Diagnostic or Therapeutic Applications.
