This is an aptamer development services to screening aptamers binds to the ATP6V1D with an affinity of 1nM~1μM.
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| Target Category | Protein |
| Target | ATP6V1D |
| Alternative Names | ATPase H+ Transporting V1 Subunit D; VATD; ATPase, H+ Transporting, Lysosomal (Vacuolar Proton Pump) ; ATPase, H+ Transporting, Lysosomal 34kDa, V1 Subunit D; V-ATPase 28 KDa Accessory Protein; V-Type Proton ATPase Subunit D; Vacuolar Proton Pump Subunit D; V-ATPase Subunit D; ATP6M; VMA8; H(+)-Transporting Two-Sector ATPase, Subunit M; ATPase, H+ Transporting Lysosomal, Member M; Vacuolar Proton Pump Delta Polypeptide; Vacuolar Proton-ATPase Subunit D; Vacuolar ATP Synthase Subunit D; Vacuolar Proton Pump D Subunit; Vacuolar H-ATPase Subunit D; V-ATPase D Subunit; ATP6V1D |
| Gene ID | 51382 |
| UniProt ID | Q9Y5K8 |
| Target Overview | This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c", and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This gene encodes the V1 domain D subunit protein. |
| Chemical Modification | N/A |
| Type | DNA |
| Length | 20-80 nt |
| Affinity (Kd) | 1nM~1μM |
| Binding Conditions/Buffer | PBS; buffer system with Serum; other |