Anti-BAX aptamer SELEX Service(Cat#: CTApt-1695)
This is an aptamer development services to screening aptamers binds to the BAX with an affinity of 1nM~1μM.
Specific Inquiry 
Specifications
| Target Category |
Protein |
| Target |
BAX |
| Alternative Names |
BCL2 Associated X, Apoptosis Regulator; BCL2L4; BCL2 Associated X Protein; Apoptosis Regulator BAX; Bcl-2-Like Protein 4; Bcl2-L-4; BCL2-Associated X Protein Omega; BCL2-Associated X Protein; Baxdelta2G9omega; Baxdelta2omega; Baxdelta2G9; BAX |
| Gene ID |
581 |
| UniProt ID |
Q07812 |
| Target Overview |
The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein forms a heterodimer with BCL2, and functions as an apoptotic activator. The association and the ratio of BAX to BCL2 also determines survival or death of a cell following an apoptotic stimulus. This protein is reported to interact with, and increase the opening of, the mitochondrial voltage-dependent anion channel (VDAC), which leads to the loss in membrane potential and the release of cytochrome c. The expression of this gene is regulated by the tumor suppressor P53 and has been shown to be involved in P53-mediated apoptosis. Multiple alternatively spliced transcript variants, which encode different isoforms, have been reported for this gene. |
| Chemical Modification |
N/A |
| Type |
DNA |
| Length |
20-80 nt |
| Affinity (Kd) |
1nM~1μM |
| Binding Conditions/Buffer |
PBS; buffer system with Serum; other |
For Research Use Only. Not for Diagnostic or Therapeutic Applications.
