Anti-EIF4G Aptamer(Cat#: CTMM-0123-MM3)
This product is an aptamer which binds to the EIF4G with an affinity of <100 nM.
Specific Inquiry 
Specifications
| Target Category |
Protein |
| Target |
EIF4G |
| Alternative Names |
Eukaryotic Translation Initiation Factor 4 Gamma, P220, PARK18, EIF4F, EIF4G, EIF-4-Gamma, EIF-4G1, EIF4GI, Eukaryotic Translation Initiation Factor 4 Gamma, 1, Eucaryotic Translation Initiation Factor 4G, EIF4-Gamma, EIF-4G |
| Gene ID |
1981 |
| UniProt ID |
Q04637 |
| Target Overview |
The protein encoded by this gene is a component of the multi-subunit protein complex EIF4F. This complex facilitates the recruitment of mRNA to the ribosome, which is a rate-limiting step during the initiation phase of protein synthesis. The recognition of the mRNA cap and the ATP-dependent unwinding of 5'-terminal secondary structure is catalyzed by factors in this complex. The subunit encoded by this gene is a large scaffolding protein that contains binding sites for other members of the EIF4F complex. A domain at its N-terminus can also interact with the poly(A)-binding protein, which may mediate the circularization of mRNA during translation. Alternative splicing results in multiple transcript variants, some of which are derived from alternative promoter usage. |
| Chemical Modification |
RNA |
| Length |
60-80 nt |
| Affinity (Kd) |
<100 nM |
| Binding Conditions/Buffer |
80 mM potassium acetate, 2.5 mM magnesium acetate, 1 mM DTT, and 20 mM Tris (pH 7.6) |
| GC Content |
0.57 |
| Molecular Weight |
22750.5 |
| nmoles/OD260 |
1.202 |
For Research Use Only. Not for Diagnostic or Therapeutic Applications.
