Anti-ESR1 (Estrogen Receptor Alpha) aptamer(Cat#: CTApt-M-831)
This product is an aptamer which binds to the ESR1 with an affinity of <20 nM.
Specific Inquiry 
Specifications
| Target Category |
Protein |
| Target |
ESR1 |
| Alternative Names |
Estrogen Receptor 1; Nuclear Receptor Subfamily 3 Group A Member 1 ; ER-Alpha; NR3A1 ; Oestrogen Receptor Alpha ; Estradiol Receptor; E2 Receptor Alpha ; Estrogen Receptor ; ESR ; Era ; ER ; Estrogen Receptor Alpha E1-N2-E2-1-2 ; Estrogen Receptor Alpha E1-E2-1-2 ; Estrogen Nuclear Receptor Alpha ; Estrogen Receptor Alpha ; ESTRR ; ESRA ; ESR1 |
| Gene ID |
2099 |
| UniProt ID |
P03372 |
| Target Overview |
This gene encodes an estrogen receptor and ligand-activated transcription factor. The canonical protein contains an N-terminal ligand-independent transactivation domain, a central DNA binding domain, a hinge domain, and a C-terminal ligand-dependent transactivation domain. The protein localizes to the nucleus where it may form either a homodimer or a heterodimer with estrogen receptor 2. The protein encoded by this gene regulates the transcription of many estrogen-inducible genes that play a role in growth, metabolism, sexual development, gestation, and other reproductive functions and is expressed in many non-reproductive tissues. The receptor encoded by this gene plays a key role in breast cancer, endometrial cancer, and osteoporosis. This gene is reported to have dozens of transcript variants due to the use of alternate promoters and alternative splicing, however, the full-length nature of many of these variants remain uncertain. |
| Chemical Modification |
DNA |
| Length |
20-40 nt |
| Affinity (Kd) |
<20 nM |
| Binding Conditions/Buffer |
50mM Tris, 150 mM Imidazole and 150 mM NaCl . |
| GC Content |
0.55 |
| Molecular Weight |
12346.1 |
| nmoles/OD260 |
2.305 |
For Research Use Only. Not for Diagnostic or Therapeutic Applications.
