Anti-Human CD4 Aptamer(Cat#: CTMM-0124-LH13)
This product is an aptamer which binds to Human CD4 domain with an affinity of 200-1000 pM.
Specific Inquiry 
Summary
Related Products & Services
Specifications
| Target Category |
Protein |
| Target |
CD4 |
| Alternative Names |
CD4 Molecule; T-Cell Surface Glycoprotein CD4; T-Cell Surface Antigen T4/Leu-3; CD4 Antigen (P55); Leu-3; T4; CD4 Receptor; CD4 Antigen; CD4mut; IMD79; OKT4D |
| Gene ID |
920 |
| UniProt ID |
P01730 |
| Target Overview |
This gene encodes the CD4 membrane glycoprotein of T lymphocytes. The CD4 antigen acts as a coreceptor with the T-cell receptor on the T lymphocyte to recognize antigens displayed by an antigen presenting cell in the context of class II MHC molecules. The CD4 antigen is also a primary receptor for entry of the human immunodeficiency virus through interactions with the HIV Env gp120 subunit. This gene is expressed not only in T lymphocytes, but also in B cells, macrophages, granulocytes, as well as in various regions of the brain. The protein functions to initiate or augment the early phase of T-cell activation, and may function as an important mediator of indirect neuronal damage in infectious and immune-mediated diseases of the central nervous system. Multiple alternatively spliced transcript variants encoding different isoforms have been identified in this gene. |
| Chemical Modification |
2'-fluoro pyrimidines |
| Type |
RNA |
| Species Reactivity |
Human |
| Length |
50-100 nt |
| Affinity (Kd) |
200-1000 pM |
| Binding Conditions/Buffer |
PBS with 2 mM MgCl2 |
| GC Content |
48.39% |
| Molecular Weight |
29512.6 g/mole |
| nmoles/OD260 |
0.899 |
For Research Use Only. Not for Diagnostic or Therapeutic Applications.
