Anti-Human CFH Aptamer(Cat#: CTWZ-0124-WZ8)

This product is an aptamer which binds to human CFH with a high affinity.

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Summary

Specifications
Target Category Protein
Target CFH
Alternative Names Complement Factor H; ARMS1; ARMD4; FHL1; HUS; HF1; HF2; HF; Age-Related Maculopathy Susceptibility 1; H Factor 2 (Complement); H Factor 1 (Complement); Beta-1H; Adrenomedullin Binding Protein; Beta-1-H-Globulin; Factor H-Like 1; H Factor 1; Factor H; AHUS1; AMBP1; CFHL3; FH
Gene ID 3075
UniProt ID P08603
Target Overview This gene is a member of the Regulator of Complement Activation (RCA) gene cluster and encodes a protein with twenty short consensus repeat (SCR) domains. This protein is secreted into the bloodstream and has an essential role in the regulation of complement activation, restricting this innate defense mechanism to microbial infections. Mutations in this gene have been associated with hemolytic-uremic syndrome (HUS) and chronic hypocomplementemic nephropathy. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
Chemical Modification 2'-fluoro pyrimidines
Type RNA
Species Reactivity Human
Length <50 nt
Binding Conditions/Buffer 20 mM HEPES, 140 mM NaCl, 2 mM MgCl2, 2 mM CaCl2, 5 mM KCl, 0.01% Tween20, 0.1% BSA, pH 7.4
GC Content 42.11%
Molecular Weight 10838.9 g/mole
nmoles/OD260 2.547
For Research Use Only. Not for Diagnostic or Therapeutic Applications.
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