Anti-Human EGFR Aptamer(Cat#: CTMM-0124-LH23)
This product is an aptamer which binds to Human EGFR domain with an affinity of 1-50 nM.
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Summary
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Specifications
| Target Category |
Protein |
| Target |
EGFR |
| Alternative Names |
Epidermal Growth Factor Receptor; ERBB1; ERRP; ERBB; Receptor Tyrosine-Protein Kinase ErbB-1; Erb-B2 Receptor Tyrosine Kinase 1; Proto-Oncogene C-ErbB-1; EC 2.7.10.1; HER1; Epidermal Growth Factor Receptor (Avian Erythroblastic Leukemia Viral (V-Erb-B) Oncogene Homolog); Erythroblastic Leukemia Viral (V-Erb-B) Oncogene Homolog (Avian); Avian Erythroblastic Leukemia Viral (V-Erb-B) Oncogene Homolog; Epidermal Growth Factor Receptor Tyrosine Kinase Domain; Cell Proliferation-Inducing Protein 61; Cell Growth Inhibiting Protein 40; EGFR VIII; EC 2.7.10; NISBD2; PIG61; MENA |
| Gene ID |
1956 |
| UniProt ID |
P00533 |
| Target Overview |
The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor, thus inducing receptor dimerization and tyrosine autophosphorylation leading to cell proliferation. Mutations in this gene are associated with lung cancer. EGFR is a component of the cytokine storm which contributes to a severe form of Coronavirus Disease 2019 (COVID-19) resulting from infection with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). |
| Chemical Modification |
2'-fluoro pyrimidines |
| Type |
RNA |
| Species Reactivity |
Human |
| Length |
100-200 nt |
| Affinity (Kd) |
1-50 nM |
| Binding Conditions/Buffer |
DPBS and 5 mM MgCl2 |
| GC Content |
48.25% |
| Molecular Weight |
36196.7 g/mole |
| nmoles/OD260 |
0.732 |
For Research Use Only. Not for Diagnostic or Therapeutic Applications.
