Anti-Human IGF2R Aptamer(Cat#: CTMM-0124-RJ23)
This product is an aptamer which binds to Human IGF2R with an affinity of 1-50 nM.
Specific Inquiry 
Specifications
| Target Category |
Protein |
| Target |
IGF2R |
| Alternative Names |
Insulin Like Growth Factor 2 Receptor; MPRI; CI-M6PR; CI-MPR; MPR300; CD222; CIMPR; M6P-R; MPR1; Cation-Independent Mannose-6-Phosphate Receptor; Insulin-Like Growth Factor II Receptor; Insulin-Like Growth Factor 2 Receptor; 300 KDa Mannose 6-Phosphate Receptor; CI Man-6-P Receptor; M6P/IGF2 Receptor; IGF-II Receptor; M6P/IGF2R; MPR 300; Cation-Independent Mannose-6 Phosphate Receptor; CD222 Antigen; M6PR; IGF2R |
| Gene ID |
3482 |
| UniProt ID |
P11717 |
| Target Overview |
This gene encodes a receptor for both insulin-like growth factor 2 and mannose 6-phosphate. The binding sites for each ligand are located on different segments of the protein. This receptor has various functions, including in the intracellular trafficking of lysosomal enzymes, the activation of transforming growth factor beta, and the degradation of insulin-like growth factor 2. Mutation or loss of heterozygosity of this gene has been association with risk of hepatocellular carcinoma. The orthologous mouse gene is imprinted and shows exclusive expression from the maternal allele; however, imprinting of the human gene may be polymorphic, as only a minority of individuals showed biased expression from the maternal allele. |
| Type |
DNA |
| Species Reactivity |
Human |
| Length |
50-100 nt |
| Affinity (Kd) |
1-50 nM |
| Binding Conditions/Buffer |
Bicarbonate, PH 7.4 |
| GC Content |
47.44% |
| Molecular Weight |
23611.4 g/mole |
| nmoles/OD260 |
1.183 |
For Research Use Only. Not for Diagnostic or Therapeutic Applications.
