Anti-Human TLR2 Aptamer(Cat#: CTMM-0124-LH43)

This product is an aptamer which binds to Human TLR2 domain with an affinity of 50-200 pM.

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Specifications
Target Category Protein
Target TLR2
Alternative Names Toll Like Receptor 2; TIL4; Toll-Like Receptor 2; CD282; Toll/Interleukin-1 Receptor-Like Protein 4; CD282 Antigen
Gene ID 7097
UniProt ID O60603
Target Overview The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. This protein is a cell-surface protein that can form heterodimers with other TLR family members to recognize conserved molecules derived from microorganisms known as pathogen-associated molecular patterns (PAMPs). Activation of TLRs by PAMPs leads to an up-regulation of signaling pathways to modulate the host's inflammatory response. This gene is also thought to promote apoptosis in response to bacterial lipoproteins. This gene has been implicated in the pathogenesis of several autoimmune diseases. Alternative splicing results in multiple transcript variants.
Type DNA
Species Reactivity Human
Length 50-100 nt
Affinity (Kd) 50-200 pM
Binding Conditions/Buffer 20 mM Tris-HCl, 100 mM NaCl and 5 mM MgCl2, pH=7.5
GC Content 56.25%
Molecular Weight 19135.4 g/mole
nmoles/OD260 1.527

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