Anti-Human VRK1 Aptamer(Cat#: CTMM-0124-LH46)

This product is an aptamer which binds to Human VRK1 domain with an affinity of 1-50 nM.

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Summary
Specifications
Target Category Protein
Target VRK1
Alternative Names VRK; VRK Serine/Threonine Kinase 1; Serine/Threonine-Protein Kinase VRK1; Vaccinia Related Kinase 1; EC 2.7.11.1; Vaccinia Virus B1R-Related Kinase 1; Vaccinia-Related Kinase 1; PCH1A; PCH1
Gene ID 7443
UniProt ID Q99986
Target Overview This gene encodes a member of the vaccinia-related kinase (VRK) family of serine/threonine protein kinases. This gene is widely expressed in human tissues and has increased expression in actively dividing cells, such as those in testis, thymus, fetal liver, and carcinomas. Its protein localizes to the nucleus and has been shown to promote the stability and nuclear accumulation of a transcriptionally active p53 molecule and, in vitro, to phosphorylate Thr18 of p53 and reduce p53 ubiquitination. This gene, therefore, may regulate cell proliferation. This protein also phosphorylates histone, casein, and the transcription factors ATF2 (activating transcription factor 2) and c-JUN.
Type DNA
Species Reactivity Human
Length 50-100 nt
Affinity (Kd) 1-50 nM
Binding Conditions/Buffer PBS, 10 mM Na3PO4, 0.15 M NaCl, MgCl2 1 mM, BSA 0.2%, pH=7.5
GC Content 62.34%
Molecular Weight 23501.2 g/mole
nmoles/OD260 1.226
For Research Use Only. Not for Diagnostic or Therapeutic Applications.
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