Anti-Mouse IDO1 Aptamer(Cat#: CTWZ-0124-WZ40)

This product is an aptamer which binds to mouse IDO1 with an affinity of 50-200 nM.

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Summary
Specifications
Target Category Protein
Target IDO1
Alternative Names Indoleamine 2,3-Dioxygenase 1; INDO; IDO; Indoleamine-Pyrrole 2,3-Dioxygenase; IDO-1; Indoleamine-Pyrrole 2,3 Dioxygenase; Indolamine 2,3 Dioxygenase; Indole 2,3-Dioxygenase; EC 1.13.11.52
Gene ID 3620
UniProt ID P14902
Target Overview This gene encodes indoleamine 2,3-dioxygenase (IDO) - a heme enzyme that catalyzes the first and rate-limiting step in tryptophan catabolism to N-formyl-kynurenine. This enzyme acts on multiple tryptophan substrates including D-tryptophan, L-tryptophan, 5-hydroxy-tryptophan, tryptamine, and serotonin. This enzyme is thought to play a role in a variety of pathophysiological processes such as antimicrobial and antitumor defense, neuropathology, immunoregulation, and antioxidant activity. Through its expression in dendritic cells, monocytes, and macrophages this enzyme modulates T-cell behavior by its peri-cellular catabolization of the essential amino acid tryptophan.
Type DNA
Species Reactivity Mouse
Length 50-100 nt
Affinity (Kd) 50-200 nM
Binding Conditions/Buffer 10 mM Tris, 150 mM NaCl, 5 mM KCl, 1 mM MgCl2, 1 mM CaCl2, pH 7.5
GC Content 52.56%
Molecular Weight 23573.3 g/mole
nmoles/OD260 1.203
For Research Use Only. Not for Diagnostic or Therapeutic Applications.
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