Short Description
Quantifies fumarate concentration.
Development Stage
Research-Grade Metabolic Assay Development
Description
The OXPHOSight™ Fumarate Assay Kit measures fumarate accumulation to investigate hypoxia response pathways and the efficacy of metabolic inhibitors in oncology. Precise metabolite quantification aids in oncometabolite research, supporting the investigation of hypoxia-inducible factor (HIF) stabilization. This tool is essential for elucidating the metabolic adaptations of cancer cells and identifying vulnerabilities for therapeutic intervention.
Features
Precise metabolite quantification aids in oncometabolite research; Supports investigation of hypoxia-inducible factor (HIF) pathways in oncology.
Process Relevance
Oncology Target Validation (Oncometabolites)
Application Stage
Target Validation
Applications
Critical for studying mitochondrial diseases.
Qualified With
Internal performance validation using reference standards under defined assay conditions.
Detection Method
Absorbance at 565 nm
Sample Type
Food, beverage and other biological samples (serum, citrate-plasma, urine, cell lysate, culture medium)
Research Areas
Oncology (Oncometabolites); Metabolic Disease
Datasheet