Excretion Products

04 ADME Products · Excretion

Excretion is the terminal phase of pharmacokinetics, encompassing the routes by which a drug and its metabolites are irreversibly eliminated from the body. Renal excretion — via glomerular filtration, active tubular secretion, and tubular reabsorption — and biliary excretion are the predominant pathways, with minor contributions from pulmonary, salivary, and faecal elimination routes.

Our Excretion portfolio provides validated in vitro tools for the characterisation of renal transporter activity, hepatic biliary efflux, tubular secretion mechanisms, and quantification of endogenous biomarkers of renal and hepatic excretory function — supporting mechanistic excretion studies and drug–drug interaction risk assessment at the elimination phase.

Renal Transporters Biliary Excretion Tubular Secretion ELISA Kits Glomerular Filtration Canalicular Transport Renal Biomarkers
4
Product Categories
Renal tools · Biliary models · Transporter kits · Biomarker ELISA
6
Species Coverage
Human · Rat · Mouse · Dog · Cynomolgus · Rabbit
1
Current Brand
BiliTrack™ — biliary and renal excretion ELISA kit series
2
Primary Excretion Routes
Renal (glomerular filtration + active tubular secretion) · Biliary (canalicular efflux)

Drug excretion determines the rate at which a compound is permanently removed from systemic circulation, directly governing terminal half-life, plasma clearance, and the duration of pharmacological activity. Renal excretion is the dominant elimination route for hydrophilic compounds and polar Phase II conjugates; it proceeds through three sequential mechanisms at the nephron — passive glomerular filtration of unbound drug, active tubular secretion mediated by OAT1, OAT3, OCT2, MATE1, and MATE2-K transporters, and passive or transporter-mediated tubular reabsorption.

Biliary excretion is the principal route for high-molecular-weight compounds (typically >500 Da), lipophilic metabolites, and glucuronide conjugates susceptible to enterohepatic recirculation. Hepatic canalicular efflux is mediated by ABC transporters — principally MRP2 (ABCC2), BCRP (ABCG2), and BSEP (ABCB11) — which actively transport substrates from hepatocytes into bile. Our portfolio encompasses the in vitro tools to characterise both excretion pathways, from renal transporter-expressing cell lines and membrane vesicles to sandwich-cultured hepatocyte biliary efflux systems and validated ELISA kits for excretory biomarkers.

Renal and hepatic excretory transporters are prominent sites of clinically significant drug–drug interactions. In vitro characterisation of OAT, OCT, MATE, MRP2, and BSEP-mediated transport and inhibition is an essential component of the regulatory excretion DDI risk assessment framework.
Product Scope at a Glance
  • 01
    Renal Excretion Tools Renal proximal tubule cells · OAT/OCT/MATE transporter cell lines · Renal S9 fractions · Creatinine and cystatin C reference standards
  • 02
    Biliary Excretion Models Sandwich-cultured hepatocytes (B-CLEAR® format) · Canalicular vesicles (MRP2, BSEP, BCRP) · Bile acid transport assay kits · Cholestasis marker reagents
  • 03
    Transporter Vesicle Systems Inside-out membrane vesicles (MRP2, BSEP, MRP3, MRP4, BCRP) · Vesicle uptake kits · ATPase activity assay reagents
  • 04
    Excretion Biomarker ELISA Kits BiliTrack™ ELISA kits — bilirubin, bile acids, creatinine, KIM-1, NGAL, cystatin C (multi-species)
Drug Excretion Pathway
GF
Glomerular Filtration
Unbound drug passively filtered at the glomerulus; rate proportional to fu,p and GFR (120 mL/min in healthy adults)
TS
Tubular Secretion
Active secretion via OAT1/3, OCT2 (uptake) and MATE1/2-K (efflux) in proximal tubule cells; principal site of renal DDIs
TR
Tubular Reabsorption
Passive reabsorption of lipophilic drug down concentration gradient; active reabsorption via PEPT2, OAT4, URAT1 in tubule
BE
Biliary Efflux
Hepatic canalicular efflux into bile via MRP2, BSEP, and BCRP; facilitates enterohepatic recirculation of glucuronide conjugates
CL
Renal / Biliary CL
CLrenal = fu,p × GFR + CLsecretion − CLreabsorption; scaled from in vitro tubular secretion and vesicle data
Section 02
Product Type
Browse Excretion products by application area and reagent class
Renal Excretion Tools

Renal tubular secretion is mediated by a vectorial transport system in proximal tubule cells: basolateral uptake transporters (OAT1, OAT3, OCT2) deliver drug from the blood to the intracellular compartment, while apical efflux transporters (MATE1, MATE2-K) secrete it into the tubular lumen. In vitro cell systems expressing these transporters enable precise measurement of renal uptake clearance, secretory transport, and inhibition constants for DDI prediction.

Renal Transporter Cell Lines
  • HEK293-OAT1 (SLC22A6) stably transfected
  • HEK293-OAT3 (SLC22A8) stably transfected
  • HEK293-OCT2 (SLC22A2) stably transfected
  • HEK293-MATE1 (SLC47A1) stably transfected
  • HEK293-MATE2-K (SLC47A2) stably transfected
  • Matched vector-control HEK293 cell lines
Renal Proximal Tubule Models
  • Human renal proximal tubule epithelial cells (RPTEC)
  • ciPTEC (conditionally immortalised proximal tubule cells)
  • MDCK-II cell line (tubular permeability model)
  • 3D tubular organoid culture kits
  • Tubular secretion assay transwell kits (OAT/OCT/MATE format)
Renal S9 & Microsomal Fractions
  • Human kidney cortex S9 fraction (pooled)
  • Human kidney microsomes (CYP1A1, 2B6, 3A5 activity)
  • Rat kidney cortex S9 and microsomes
  • Cynomolgus monkey kidney S9 fractions
  • Renal cytosol (AO, SULT activity)
Renal Transport Assay Reagents
  • OAT1/3 probe substrate set (PAH, estrone-3-sulfate)
  • OCT2 probe substrate (metformin, ASP+)
  • MATE1/2-K probe substrate (metformin, tetraethylammonium)
  • Renal transport assay buffer systems (pH 7.4)
  • Reference inhibitor panel (probenecid, quinidine, cimetidine)
Biliary Excretion Models

Biliary excretion of drugs and their metabolites is driven by canalicular ABC transporters expressed on the apical membrane of hepatocytes. Sandwich-cultured hepatocytes (SCH) maintain functional bile canalicular networks and polarised transporter expression, enabling direct measurement of biliary clearance (CLbile) and the biliary excretion index (BEI) in vitro.

Sandwich-Cultured Hepatocytes
  • Cryopreserved human hepatocytes (SCH-grade, platable)
  • Rat hepatocytes (SCH-grade, in situ collagen overlay)
  • Dog (beagle) and cynomolgus monkey SCH-grade hepatocytes
  • Collagen I sandwich culture matrix kits (2-overlay system)
  • Matrigel overlay hepatocyte culture kits
Biliary Function Assay Kits
  • B-CLEAR® biliary excretion index (BEI) assay kits
  • HBSS-Ca2+ / EGTA-Ca2+ buffer pair systems (BEI protocol)
  • CLF (cholyl-lysyl-fluorescein) biliary integrity marker
  • CDFDA (canalicular function dye, fluorescent)
  • CLbile calculation and data normalisation templates
Bile Acid & Cholestasis Tools
  • Bile acid transport assay kits (BSEP substrate: taurocholate)
  • Total bile acid quantification kits (enzymatic colorimetric)
  • BSEP inhibition assay reagents (vesicle format)
  • Cholestasis biomarker reference standards (ALT, AST, ALP)
  • Hepatocyte cholestasis toxicity assessment kits
Enterohepatic Recirculation Tools
  • β-Glucuronidase (bacterial, intestinal hydrolysis model)
  • Bile salt hydrolase activity kits
  • Intestinal microsomal fraction (Phase II reversal studies)
  • Conjugate re-absorption assay reagents (Caco-2 format)
  • Glucuronide reference standards for hydrolysis assays
Transporter Membrane Vesicle Systems

Inside-out membrane vesicles derived from cells overexpressing canalicular and renal efflux transporters enable direct measurement of ATP-dependent substrate uptake kinetics and inhibition parameters in the absence of confounding intracellular metabolism. Vesicle systems are the gold-standard in vitro model for BSEP and MRP2 inhibition assessment and for canalicular drug transport characterisation.

Hepatic Canalicular Vesicles
  • MRP2 (ABCC2) inside-out membrane vesicles
  • BSEP (ABCB11) inside-out vesicles — taurocholate transport
  • BCRP (ABCG2) vesicles (hepatic / intestinal isoform)
  • MRP3 (ABCC3) and MRP4 (ABCC4) vesicles
  • Matched control vesicles (vector-transfected cells)
Vesicle Uptake Assay Kits
  • Rapid filtration vesicle uptake assay kits (96-well)
  • ATP regenerating system (creatine kinase / creatine phosphate)
  • AMP (negative control nucleotide) reaction kits
  • ATPase activity assay kits (colorimetric, 96-well)
  • Probe substrate and inhibitor reference sets per transporter
Renal Efflux Vesicles
  • MRP4 (ABCC4) vesicles (renal apical efflux model)
  • MATE1 / MATE2-K vesicles (tubular secretion model)
  • P-gp (ABCB1) vesicles (renal and intestinal efflux)
  • OAT3 and OCT2 overexpressing membrane preparations
  • Multi-transporter vesicle inhibition panel
Vesicle Quality Controls
  • Protein content normalisation reagents (BCA, Bradford)
  • Orientation assessment kits (inside-out verification)
  • Functional activity QC compounds per transporter
  • Km / Vmax reference standards for kinetic validation
  • Freeze-thaw stability verification protocols
Excretion Biomarker ELISA Kits

Quantification of endogenous biomarkers in plasma, urine, and bile enables non-invasive assessment of renal and hepatic excretory function in both in vitro and in vivo study designs. ELISA kits provide sensitive, species-specific measurements of established and emerging excretion biomarkers, supporting mechanistic studies and safety monitoring applications.

Renal Function Biomarker Kits
  • Creatinine ELISA kit (plasma and urine, multi-species)
  • Cystatin C ELISA kit (human, rat, mouse)
  • KIM-1 (Kidney Injury Molecule-1) ELISA kit
  • NGAL (Neutrophil Gelatinase-Associated Lipocalin) ELISA kit
  • Clusterin (CLU) renal injury biomarker ELISA kit
Biliary & Hepatic Biomarker Kits
  • Total bilirubin quantification ELISA kit (plasma / bile)
  • Direct (conjugated) bilirubin ELISA kit
  • Total bile acid ELISA kit (serum and bile, multi-species)
  • Individual bile acid ELISA panels (taurocholate, glycocholate)
  • FGF19 / FGF21 bile acid signalling biomarker ELISA kits
Urinary Excretion Marker Kits
  • Urinary albumin ELISA kit (microalbuminuria detection)
  • β2-Microglobulin urine ELISA kit (tubular dysfunction marker)
  • Urinary NAG (N-acetyl-β-D-glucosaminidase) activity kit
  • Urinary 8-hydroxy-2′-deoxyguanosine (oxidative stress) ELISA
  • Urine protein normalisation reagents (creatinine-adjusted)
Transporter-Related Endogenous Markers
  • Copeptin (vasopressin precursor) ELISA — tubular water reabsorption
  • Endogenous OAT substrate panel (kynurenic acid, indoxyl sulfate)
  • OCT2 endogenous substrate ELISA (N1-methylnicotinamide)
  • Plasma and urine creatine ELISA kit
  • Endogenous MATE substrate quantification kits
Section 03
Search by Brands
Current and forthcoming proprietary brands within the Excretion portfolio
Featured Brand · Excretion Series
BiliTrack™
Validated ELISA kit series for biliary, renal, and excretory function biomarker quantification

BiliTrack™ is Creative Biolabs' proprietary ELISA kit series for the quantification of endogenous biliary and renal excretion biomarkers across preclinical and translational study designs. Each kit is optimised for plasma, serum, urine, and bile matrices, and validated for use across human and multiple preclinical species. BiliTrack™ kits provide sensitive, specific measurements of bilirubin species, bile acids, and renal injury markers, supporting in vitro hepatotoxicity assessment, in vivo excretion profiling, and biomarker-based drug safety evaluation.

  • Validated across plasma, urine, serum, and bile matrices
  • Human, rat, mouse, dog, and monkey species coverage
  • Lot-specific sensitivity and cross-reactivity data supplied
  • Ready-to-use format with all reagents included
  • Suitable for 96-well plate and microplate reader detection
  • Quantification range and LLOQ defined per kit
6
biomarker categories covered
5
validated species (human + 4 preclinical)
4
compatible sample matrices
Brand Coming Soon
A new proprietary brand for renal transporter assay kits is in development.
Brand Coming Soon
A dedicated biliary efflux vesicle and SCH assay brand is planned for this portfolio.
Brand Coming Soon
Further excretion portfolio brands covering additional assay formats are forthcoming.
Section 04
Products
Full Excretion product catalogue — filter by category

The product catalogue below is ready to receive SKU data. Use the filter chips to browse by dimension. Each product entry carries a catalogue number, product name, category classification, species applicability, format, and a datasheet link.

For Research Use Only | Not For Clinical Use

Filters

[Cat#: ITS-0326-HM35]

Vesitra™ BSEP Membrane Vesicles
Product Type Transporter Vesicles
Brand Vesitra™
Development Stage ADME
ADME Research Domain Excretion
Short Description High-purity inside-out membrane vesicles for direct ATP-dependent BSEP transport assays, the definitive tool for predicting cholestatic hepatotoxicity.

[Cat#: ITS-0326-HM36]

Vesitra™ Human MRP1 Membrane Vesicles
Product Type Transporter Vesicles
Species Human
Brand Vesitra™
Development Stage ADME
ADME Research Domain Excretion
Short Description Premium inside-out vesicles for evaluating MRP1-mediated efflux of conjugated metabolites and chemotherapeutic agents.

[Cat#: ITS-0326-HM37]

Vesitra™ MRP2 Membrane Vesicles
Product Type Transporter Vesicles
Brand Vesitra™
Development Stage ADME
ADME Research Domain Excretion
Short Description Specialized vesicular model for deciphering canalicular efflux and biliary excretion of xenobiotics.

[Cat#: ITS-0326-HM38]

Vesitra™ Human MRP3 Membrane Vesicles
Product Type Transporter Vesicles
Species Human
Brand Vesitra™
Development Stage ADME
ADME Research Domain Excretion
Short Description A dedicated vesicle model for investigating basolateral hepatic efflux and enterohepatic circulation dynamics.

[Cat#: ITS-0326-HM39]

Vesitra™ Human MRP4 Membrane Vesicles
Product Type Transporter Vesicles
Species Human
Brand Vesitra™
Development Stage ADME
ADME Research Domain Excretion
Short Description Versatile vesicle platform for analyzing the active transport of cyclic nucleotides, antiviral drugs, and prostaglandins.

[Cat#: ITS-0326-HM40]

Vesitra™ Human MRP5 Membrane Vesicles
Product Type Transporter Vesicles
Species Human
Brand Vesitra™
Development Stage ADME
ADME Research Domain Excretion
Short Description Specialized vesicular tool for exploring the efflux of cyclic nucleotides and fluorinated antineoplastic agents.

[Cat#: ITS-0326-HM41]

Vesitra™ Human P-gp (MDR1) Membrane Vesicles
Product Type Transporter Vesicles
Species Human
Brand Vesitra™
Development Stage ADME
ADME Research Domain Excretion
Short Description High-performance inside-out membrane vesicles for direct evaluation of ATP-dependent P-gp efflux activity.

[Cat#: ITS-0326-HM42]

Vesitra™ BCRP Membrane Vesicles
Product Type Transporter Vesicles
Brand Vesitra™
Development Stage ADME
ADME Research Domain Excretion
Short Description Specialized inside-out vesicular model for precise, interference-free measurement of BCRP-mediated drug efflux.

[Cat#: ITS-0326-HM1]

Vesitra™ Human OATP1B1 Stable HEK293 Cell Line
Product Type Transporter Cell Line
Brand Vesitra™
Development Stage ADME
ADME Research Domain Metabolism; Absorption; Excretion
Short Description High-fidelity cell line stably expressing human OATP1B1, designed for hepatic targeted screening and high-throughput DDI evaluation.

[Cat#: ITS-0326-HM2]

Vesitra™ Human OATP1B3 Stable HEK293 Cell Line
Product Type Transporter Cell Line
Brand Vesitra™
Development Stage ADME
ADME Research Domain Metabolism; Absorption; Excretion
Short Description A stable OATP1B3 expression model for accurately simulating the uptake of macromolecular and peptide drugs at the hepatocyte basolateral membrane.

[Cat#: ITS-0326-HM3]

Vesitra™ Human OATP2B1 Stable HEK293 Cell Line
Product Type Transporter Cell Line
Brand Vesitra™
Development Stage ADME
ADME Research Domain Metabolism; Absorption; Excretion
Short Description A robust OATP2B1 stable model supporting mildly acidic environments, ideal for dual-function studies of intestinal absorption and hepatic distribution.

[Cat#: ITS-0326-HM4]

Vesitra™ Human OATP1A2 Stable HEK293 Cell Line
Product Type Transporter Cell Line
Brand Vesitra™
Development Stage ADME
ADME Research Domain Metabolism; Absorption; Excretion
Short Description The ideal in vitro OATP1A2 model for penetrating the blood-brain barrier (BBB) and multi-tissue distribution research.

[Cat#: ITS-0326-HM5]

Vesitra™ Human OAT1 Stable HEK293 Cell Line
Product Type Transporter Cell Line
Brand Vesitra™
Development Stage ADME
ADME Research Domain Metabolism; Absorption; Excretion
Short Description A regulatory-compliant OAT1 stable cell line serving as the gold standard for renal tubular secretion and nephrotoxicity studies.

[Cat#: ITS-0326-HM6]

Vesitra™ Human OAT2 Stable HEK293 Cell Line
Product Type Transporter Cell Line
Brand Vesitra™
Development Stage ADME
ADME Research Domain Metabolism; Absorption; Excretion
Short Description An advanced OAT2 model for capturing atypical drug clearance pathways, serving as a cutting-edge tool for dual hepatic-renal transport studies.

[Cat#: ITS-0326-HM7]

Vesitra™ Human OAT3 Stable HEK293 Cell Line
Product Type Transporter Cell Line
Brand Vesitra™
Development Stage ADME
ADME Research Domain Metabolism; Absorption; Excretion
Short Description A comprehensive OAT3 model for decoding renal anion secretion, preferred for screening macromolecules and conjugated metabolites.

[Cat#: ITS-0326-HM8]

Vesitra™ Human OCT1 Stable HEK293 Cell Line
Product Type Transporter Cell Line
Brand Vesitra™
Development Stage ADME
ADME Research Domain Metabolism; Absorption; Excretion
Short Description The cornerstone model for hepatic cation targeting and pharmacodynamic studies, featuring high-sensitivity OCT1 stable expression.

[Cat#: ITS-0326-HM9]

Vesitra™ Human OCT2 Stable HEK293 Cell Line
Product Type Transporter Cell Line
Brand Vesitra™
Development Stage ADME
ADME Research Domain Metabolism; Absorption; Excretion
Short Description A fully ICH-compliant OCT2 model unlocking the key window into renal tubular secretion and accumulation of cationic drugs.

[Cat#: ITS-0326-HM10]

Vesitra™ Human MATE1 Stable HEK293 Cell Line
Product Type Transporter Cell Line
Brand Vesitra™
Development Stage ADME
ADME Research Domain Metabolism; Absorption; Excretion
Short Description A pioneering tool for simulating proton-driven efflux, the MATE1 stable line aids in resolving the final clearance steps in kidneys and liver.

[Cat#: ITS-0326-HM11]

Vesitra™ Human MATE2-K Stable HEK293 Cell Line
Product Type Transporter Cell Line
Brand Vesitra™
Development Stage ADME
ADME Research Domain Metabolism; Absorption; Excretion
Short Description An exclusive renal efflux transport model designed for highly refined renal excretion DDI evaluations.

[Cat#: ITS-0326-HM12]

Vesitra™ Human NTCP Stable HEK293 Cell Line
Product Type Transporter Cell Line
Brand Vesitra™
Development Stage ADME
ADME Research Domain Metabolism; Absorption; Excretion
Short Description A dual-purpose tool for bile acid homeostasis and viral infection mechanisms, featuring a high-expression NTCP screening line.

[Cat#: ITS-0326-HM13]

Vesitra™ Human PEPT1 Stable HEK293 Cell Line
Product Type Transporter Cell Line
Brand Vesitra™
Development Stage ADME
ADME Research Domain Metabolism; Absorption; Excretion
Short Description A highly efficient PEPT1 stable cell model engineered to simulate intestinal absorption of peptide-based therapeutics.

[Cat#: ITS-0326-HM14]

Vesitra™ Human PEPT2 Stable HEK293 Cell Line
Product Type Transporter Cell Line
Brand Vesitra™
Development Stage ADME
ADME Research Domain Metabolism; Absorption; Excretion
Short Description A high-sensitivity PEPT2 model focused on peptide reabsorption studies in the kidneys and central nervous system.

[Cat#: ITS-0326-HM15]

Vesitra™ Human OCT3 Stable HEK293 Cell Line
Product Type Transporter Cell Line
Brand Vesitra™
Development Stage ADME
ADME Research Domain Metabolism; Absorption; Excretion
Short Description A versatile tool for broadly distributed cation transport research, capturing non-tissue-specific OCT3 uptake kinetics.

[Cat#: ITS-0326-HM16]

Vesitra™ Human OCTN1 Stable HEK293 Cell Line
Product Type Transporter Cell Line
Brand Vesitra™
Development Stage ADME
ADME Research Domain Metabolism; Absorption; Excretion
Short Description A stable OCTN1 expression model tailored for studying antioxidant and cationic equilibrium.

[Cat#: ITS-0326-HM17]

Vesitra™ Human OCTN2 Stable HEK293 Cell Line
Product Type Transporter Cell Line
Brand Vesitra™
Development Stage ADME
ADME Research Domain Metabolism; Absorption; Excretion
Short Description The benchmark OCTN2 stable cell line for studying carnitine cycling and drug-induced efflux blockade.

[Cat#: ITS-0326-HM18]

Vesitra™ Human OAT4 Stable HEK293 Cell Line
Product Type Transporter Cell Line
Brand Vesitra™
Development Stage ADME
ADME Research Domain Metabolism; Absorption; Excretion
Short Description A renal apical membrane anion exchange model focusing on OAT4-mediated excretion and reabsorption.

[Cat#: ITS-0326-HM19]

Vesitra™ Human OAT7 Stable HEK293 Cell Line
Product Type Transporter Cell Line
Brand Vesitra™
Development Stage ADME
ADME Research Domain Metabolism; Absorption; Excretion
Short Description An exclusive tool for hepatic sulfate transport research, decoding OAT7-mediated anion uptake.

[Cat#: ITS-0326-HM20]

Vesitra™ Human ASBT Stable HEK293 Cell Line
Product Type Transporter Cell Line
Brand Vesitra™
Development Stage ADME
ADME Research Domain Metabolism; Absorption; Excretion
Short Description An essential model for ileal bile acid retrieval studies, the ASBT stable expression system empowers enterohepatic circulation analysis.

[Cat#: ITS-0326-HM21]

Vesitra™ Human URAT1 Stable HEK293 Cell Line
Product Type Transporter Cell Line
Brand Vesitra™
Development Stage ADME
ADME Research Domain Metabolism; Absorption; Excretion
Short Description The core target model for gout drug development, delivering precise simulation of URAT1-mediated uric acid reabsorption.

[Cat#: ITS-0326-HM22]

Vesitra™ Human OSTα/β Stable HEK293 Cell Line
Product Type Transporter Cell Line
Brand Vesitra™
Development Stage ADME
ADME Research Domain Metabolism; Absorption; Excretion
Short Description A unique heterodimeric transport model deciphering OSTα/β-mediated ATP-independent efflux.

[Cat#: ITS-0326-HM23]

Vesitra™ Human ENT1 Stable HEK293 Cell Line
Product Type Transporter Cell Line
Brand Vesitra™
Development Stage ADME
ADME Research Domain Metabolism; Absorption; Excretion
Short Description The foundational model for transmembrane nucleoside transport, providing a robust functional validation platform for ENT1.

[Cat#: ITS-0326-HM24]

Vesitra™ Human ENT2 Stable HEK293 Cell Line
Product Type Transporter Cell Line
Brand Vesitra™
Development Stage ADME
ADME Research Domain Metabolism; Absorption; Excretion
Short Description An ENT2 stable expression model focused on nucleoside uptake research in muscle and specialized tissues.

[Cat#: ITS-0326-HM25]

Vesitra™ Human CNT1 Stable HEK293 Cell Line
Product Type Transporter Cell Line
Brand Vesitra™
Development Stage ADME
ADME Research Domain Metabolism; Absorption; Excretion
Short Description A sodium-dependent pyrimidine nucleoside transport model empowering antiviral research through the CNT1 stable line.

[Cat#: ITS-0326-HM26]

Vesitra™ Human CNT2 Stable HEK293 Cell Line
Product Type Transporter Cell Line
Brand Vesitra™
Development Stage ADME
ADME Research Domain Metabolism; Absorption; Excretion
Short Description A CNT2 model dedicated to purine nucleoside active transport research, decoding energy-dependent uptake mechanisms.

[Cat#: ITS-0326-HM27]

Vesitra™ Human CNT3 Stable HEK293 Cell Line
Product Type Transporter Cell Line
Brand Vesitra™
Development Stage ADME
ADME Research Domain Metabolism; Absorption; Excretion
Short Description A broad-spectrum concentrative nucleoside transport model, featuring high-capacity CNT3 stable expression for both purine and pyrimidine analogs.

[Cat#: ITS-0326-HM28]

Vesitra™ Human P-gp Stable MDCK Cell Line
Product Type Transporter Cell Line
Brand Vesitra™
Development Stage ADME
ADME Research Domain Metabolism; Absorption; Excretion
Short Description A polarized MDCK cell model stably expressing human P-gp, the gold standard for assessing bidirectional permeability and brain penetration.

[Cat#: ITS-0326-HM29]

Vesitra™ Human BCRP Stable MDCK Cell Line
Product Type Transporter Cell Line
Brand Vesitra™
Development Stage ADME
ADME Research Domain Metabolism; Absorption; Excretion
Short Description A robust polarized model engineered for BCRP-mediated bidirectional transport, crucial for resolving multidrug resistance and drug disposition.

[Cat#: ITS-0326-HM30]

Vesitra™ Mouse MDR1 Stable MDCK Cell Line
Product Type Transporter Cell Line
Brand Vesitra™
Development Stage ADME
ADME Research Domain Metabolism; Absorption; Excretion
Short Description A polarized MDCK cell model stably expressing murine MDR1, essential for preclinical mouse pharmacokinetic and BBB permeability evaluations.

[Cat#: ITS-0326-HM31]

Vesitra™ Rat MDR1 Stable MDCK Cell Line
Product Type Transporter Cell Line
Brand Vesitra™
Development Stage ADME
ADME Research Domain Metabolism; Absorption; Excretion
Short Description A highly reliable rat MDR1 stable MDCK model for evaluating drug efflux in rodent preclinical toxicity and ADME studies.

[Cat#: ITS-0326-HM32]

Vesitra™ Dog MDR1 Stable MDCK Cell Line
Product Type Transporter Cell Line
Brand Vesitra™
Development Stage ADME
ADME Research Domain Metabolism; Absorption; Excretion
Short Description Canine MDR1 stable expression MDCK model, vital for interpreting preclinical dog DMPK data and assessing breed-specific toxicity risks.

[Cat#: ITS-0326-HM33]

Vesitra™ Cynomolgus MDR1 Stable MDCK Cell Line
Product Type Transporter Cell Line
Brand Vesitra™
Development Stage ADME
ADME Research Domain Metabolism; Absorption; Excretion
Short Description A premium cynomolgus monkey MDR1 expression model, delivering the highest translational relevance for non-human primate DMPK bridging studies.

[Cat#: ITS-0326-HM34]

Vesitra™ Rat URAT1 Stable HEK293 Cell Line
Product Type Transporter Cell Line
Brand Vesitra™
Development Stage ADME
ADME Research Domain Metabolism; Absorption; Excretion
Short Description A stable HEK293 cell line expressing rat URAT1, designed for the preclinical assessment of uric acid transport and gout therapeutics.

[Cat#: ITS-0326-HM43]

Vesitra™ Uptake Transporter Cell Panel
Product Type Cell Panel
Brand Vesitra™
Development Stage ADME
ADME Research Domain Metabolism; Absorption; Excretion
Short Description A ready-to-use, comprehensive bundle of stable HEK293 cell lines expressing key human SLC transporters, designed for high-throughput uptake assays and regulatory DDI screening.

[Cat#: ITS-0326-HM44]

Vesitra™ Efflux Transporter Cell Panel
Product Type Cell Panel
Brand Vesitra™
Development Stage ADME
ADME Research Domain Metabolism; Absorption; Excretion
Short Description A specialized suite of stable MDCK-II cell lines expressing critical human ABC transporters, optimized for bidirectional transport assays and efflux ratio determination.

[Cat#: ITS-0326-HM45]

Vesitra™ Human Mock HEK293 Cell Line
Product Type Transporter Cell Line
Brand Vesitra™
Development Stage ADME
ADME Research Domain Metabolism; Absorption; Excretion
Short Description The essential negative control cell line transfected with an empty vector, required for determining background transport activity.

[Cat#: ITS-0326-WB127]

BiliTrack™ Rat gamma-Glutamyltransferase 5 (GGT5) ELISA Kit
Product Type ELISA Kit
Species Rat
Brand BiliTrack™
Development Stage ADME
ADME Research Domain Excretion
Short Description Quantitatively detects rat GGT5 protein levels in biological samples using a sensitive sandwich ELISA assay.

[Cat#: ITS-0326-WB128]

BiliTrack™ Mouse Glutathione Hydrolase 1 Proenzyme (GGT1) ELISA Kit
Product Type ELISA Kit
Species Mouse
Brand BiliTrack™
Development Stage ADME
ADME Research Domain Excretion
Short Description Quantitatively detects mouse GGT1 protein levels in biological samples using a sensitive ELISA assay.

[Cat#: ITS-0326-WB129]

BiliTrack™ Human Gamma-Glutamyltransferase 2 (GGT2) ELISA Kit
Product Type ELISA Kit
Species Human
Brand BiliTrack™
Development Stage ADME
ADME Research Domain Excretion
Short Description Quantitatively detects human GGT2 protein levels in biological samples using a high-sensitivity sandwich ELISA assay.

[Cat#: ITS-0326-WB130]

BiliTrack™ Precision Quantitative Human Gamma-Glutamyltransferase 2 (GGT2) ELISA Kit
Product Type ELISA Kit
Species Human
Brand BiliTrack™
Development Stage ADME
ADME Research Domain Excretion
Short Description Precisely quantifies human GGT2 protein levels in biological samples using a highly sensitive sandwich ELISA assay.

[Cat#: ITS-0326-WB131]

BiliTrack™ Human Gamma-glutamyltransferase 6 (GGT6) ELISA Kit
Product Type ELISA Kit
Species Human
Brand BiliTrack™
Development Stage ADME
ADME Research Domain Excretion
Short Description Quantitatively measures human GGT6 protein levels in biological samples using a high-sensitivity ELISA assay.
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