Cytokine-expressing Oncolytic Vaccinia Virus Western Reserve (ΔK3L), pSL-(IL-21) (CyOV-0120WQ)

This product is a IL-21 expressing oncolytic vaccinia virus, which is based on VACV-WR with K3L deleted. IL-21 has potent regulatory effects on cells of the immune system, including natural killer (NK) cells and cytotoxic T cells that can destroy virally infected or cancerous cells. The deletion of K3L and IL-21 expressing could enhance the immune activity. This product can also be used in oncolytic virotherapy research and vaccinie application.

Specifications
Family Poxviridae
Species Vaccinia virus
Serotype Western Reserve
Backbone VACV-WR(ΔK3L)
Backbone Background VACV-WR strain derived from Wyeth through passaging in mice and shown high tumor selectivity and strong oncolytic effect in mouse models.The engineered VACV-WR could further enhance the immune activity and the efficacy of cancer therapies.
Gene Modification ΔK3L
Promoter pSL
Transgene IL-21
Type of Transgene Cytokine
Related Target/Protein Interleukin 21
Capsid Modification None
Titer >1*10^8 PFU
Related Diseases Tumor
Transgene
Alternative Names Za11; IL-21; CVID11
Gene ID 59067
Information
Introduction This gene encodes a member of the common-gamma chain family of cytokines with immunoregulatory activity. The encoded protein plays a role in both the innate and adaptive immune responses by inducing the differentiation, proliferation and activity of multiple target cells including macrophages, natural killer cells, B cells and cytotoxic T cells. Dysregulation of this gene plays a role in multiple immune-mediated diseases including lupus, psoriasis and chronic inflammatory diseases. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
All services and products are for lab research only, not for any clinical use.

Other products

Contact Us

  • 1-631-466-5530
    44-207-097-1828
  • 1-631-207-8356

Contact Us

Copyright © 2007 - 2021 Creative Biolabs. All Rights Reserved