Name: Recombinant Anti-albumin x Anti-TNF Bispecific Antibody (Fab-sdAb-Fc)
SKU: FABVC-357
Rating: 5 (1 reviews)

Recombinant Anti-albumin x Anti-TNF Bispecific Antibody (Fab-sdAb-Fc) requires expression of three polypeptide chains, encoding two heavy chains (Fc-containing chains) and one light chain, respectively. The Fab of anti-albumin antibody variable domain is fused to the Fc-knob domain with a hinge region and the same as the sdAb of anti-TNF to the Fc-hole domain, or vice versa. The Fab-Fc and sdAb-Fc fragments can be paired via the interaction of the Fc regions. This BsAb can act as PK-modulated ligand antagonist. It is designed for the research of Lupus and rheumatoid arthritis therapy.

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Specifications

Targets

albumin & TNF

Type

Fab-scFv/sdAb-Fc

Species Reactivity

Human

Application

FuncS; Promising therapeutic agent

Related Disease

Systemic lupus erythematosus (SLE); Rheumatoid arthritis (RA)

Host Animal 1

Mouse

Host Animal 2

llama

Targets

Target 1

albumin

Gene ID

213

UniProt ID

P02768

Alternative Names

ALB; albumin; HAS; PRO0883; PRO0903; PRO1341

Target 2

TNF

Gene ID

7124

UniProt ID

P01375

Alternative Names

TNF; tumor necrosis factor; DIF; TNFA; TNFSF2; TNF-alpha; TNFα; cachectin; APC1 protein; TNF, monocyte-derived; TNF-α; TNF, macrophage-derived; tumor necrosis factor-alpha; tumor necrosis factor ligand superfamily member 2

Our products and services are for research use only, and not for use in diagnostic or therapeutic procedures.

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Recombinant Anti-albumin x Anti-TNF Bispecific Antibody (Fab-sdAb-Fc) (CAT#: FABVC-357)

Specifications

Targets

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