Name: Recombinant Anti-albumin x Anti-TNF Bispecific Antibody (sdAb-Fc-sdAb)
SKU: HCAB-002
Rating: 5 (1 reviews)

Recombinant Anti-albumin x Anti-TNF Bispecific Antibody (sdAb-Fc-sdAb, Tetravalent Heavy Chain-only Antibody, Tetravalent HCAb) is symmetric protein with two pairs of single domain antibodies (sdAb), from anti-albumin and anti-TNF antibodies, fused to the N-terminus and C-terminus of the Fc separately. This BsAb is bispecific, tetravelant, 2+2 antigen-binding valency. It can act as PK-modulated ligand antagonist. It is designed for the research of Lupus and rheumatoid arthritis therapy.

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Specifications

Targets

albumin & TNF

Type

sdAb-Fc-sdAb

Species Reactivity

Human

Application

FuncS; Promising therapeutic agent

Related Disease

Systemic lupus erythematosus (SLE); Rheumatoid arthritis (RA)

Host Animal 1

llama

Host Animal 2

llama

Targets

Target 1

albumin

Gene ID

285

UniProt ID

O15123

Alternative Names

ANGPT2; Ang2; angiopoietin 2; ANG2; AGPT2; angiopoietin-2; ANG-2; Tie2-ligand; angiopoietin-2B; angiopoietin-2a

Target 2

TNF

Gene ID

7422

UniProt ID

P15692

Alternative Names

VEGFA; vascular endothelial growth factor A; VPF; VEGF; MVCD1; vascular permeability factor

Our products and services are for research use only, and not for use in diagnostic or therapeutic procedures.

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Recombinant Anti-albumin x Anti-TNF Bispecific Antibody (sdAb-Fc-sdAb) (CAT#: HCAB-002)

Specifications

Targets

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