Recombinant Anti-albumin x Anti-TNF Bispecific Antibody (Fv-IgG) is an appended IgG format, which has 2+2 antigen-binding valency. This dual variable domain IgG is generated by appending variable domains of an anti-albumin IgG with similar domains from an anti-TNF antibody via short peptide linkers, or vice versa. This BsAb can act as PK-modulated ligand antagonist. It is designed for the research of Lupus and rheumatoid arthritis therapy.
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