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Recombinant Anti-IL12 x Anti-IL18 Bispecific Antibody (scFv-CH3)  (CAT#: BSFC-171)

Recombinant Anti-IL12 x Anti-IL18 Bispecific Antibody (scFv-CH3) contains two chains. The anti-IL12 scFv is fused to the Knob-CH3 domain via a hinge region and the same as the anti-IL18 scFv to the Hole-CH3 domain, or vice versa. The KIH CH3 domains can facilitate to form a heterodimer and this bivalent binding leads to improvement in avidity. This BsAb can bind and inactivate two ligands simultaneously. It is designed for the research of Arthritis therapy.
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Specifications

Targets
IL12 & IL18
Type
scFv-based Bispecific Fragments
Species Reactivity
Human
Application
FuncS; Promising therapeutic agent
Related Disease
Arthritis

Targets

Target 1
IL12
Gene ID
UniProt ID
Alternative Names
P35; CLMF; NFSK; NKSF1; IL-12A; IL12; IL-12; interleukin 12A
Target 2
IL18
Gene ID
UniProt ID
Alternative Names
IGIF; IL-18; IL-1g; IL1F4; interleukin 18; IL18
Our products and services are for research use only, and not for use in diagnostic or therapeutic procedures.
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