This is an aptamer development services to screening aptamers binds to the BCL6 with an affinity of 1nM~1μM.
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| Target Category | Protein |
| Target | BCL6 |
| Alternative Names | BCL6 Transcription Repressor; Zinc Finger Protein 51; ZBTB27; BCL5; LAZ3; Zinc Finger And BTB Domain-Containing Protein 27; B-Cell Lymphoma 6 Protein; B-Cell Lymphoma 5 Protein; B Cell CLL/Lymphoma 6; Protein LAZ-3; BCL6A; ZNF51; BCL-5; BCL-6; Lymphoma-Associated Zinc Finger Gene On Chromosome 3; Cys-His2 Zinc Finger Transcription Factor; Zinc Finger Transcription Factor BCL6S; B-Cell Lymphoma 6 Protein Transcript; BCL6, Transcription Repressor; BCL6 |
| Gene ID | 604 |
| UniProt ID | P41182 |
| Target Overview | The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal POZ domain. This protein acts as a sequence-specific repressor of transcription, and has been shown to modulate the transcription of STAT-dependent IL-4 responses of B cells. This protein can interact with a variety of POZ-containing proteins that function as transcription corepressors. This gene is found to be frequently translocated and hypermutated in diffuse large-cell lymphoma (DLCL), and may be involved in the pathogenesis of DLCL. Alternatively spliced transcript variants encoding different protein isoforms have been found for this gene. |
| Chemical Modification | N/A |
| Type | DNA |
| Length | 20-80 nt |
| Affinity (Kd) | 1nM~1μM |
| Binding Conditions/Buffer | PBS; buffer system with Serum; other |