Anti-Human BCL6 Aptamer(Cat#: CTMM-0124-RJ63)

This product is an aptamer which binds to Human BCL6 with a high affinity.

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5’ Modification
 
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Specifications
Target Category Protein
Target BCL6
Alternative Names BCL6 Transcription Repressor; ZBTB27; LAZ3; BCL5; Zinc Finger Protein 51; BCL6A; ZNF51; Zinc Finger And BTB Domain-Containing Protein 27; B-Cell Lymphoma 6 Protein; B-Cell Lymphoma 5 Protein; B Cell CLL/Lymphoma 6; Protein LAZ-3; BCL-5; BCL-6; Lymphoma-Associated Zinc Finger Gene On Chromosome 3; Cys-His2 Zinc Finger Transcription Factor; Zinc Finger Transcription Factor BCL6S; B-Cell Lymphoma 6 Protein Transcript; BCL6, Transcription Repressor; BCL6
Gene ID 604
UniProt ID P41182
Target Overview The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal POZ domain. This protein acts as a sequence-specific repressor of transcription, and has been shown to modulate the transcription of STAT-dependent IL-4 responses of B cells. This protein can interact with a variety of POZ-containing proteins that function as transcription corepressors. This gene is found to be frequently translocated and hypermutated in diffuse large-cell lymphoma (DLCL), and may be involved in the pathogenesis of DLCL. Alternatively spliced transcript variants encoding different protein isoforms have been found for this gene.
Type Peptide
Species Reactivity Human; Mouse
Length <50 nt
Binding Conditions/Buffer 0.5% Triton X-100, 10 mM Tris, 10 mM NaCl, 3 mM MgCl2 and Complete Protease inhibitor cocktail and dimethyl sulphoxide, pH 7.5
Molecular Weight 1187.3 g/mole

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For Research Use Only. Not for Diagnostic or Therapeutic Applications.
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