Anti-Human ANG Aptamer(Cat#: CTMM-0124-LH3)

This product is an aptamer which binds to Human ANG domain with an affinity of 1-50 nM.

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5’ Modification
 
3’ Modification
 
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Specifications
Target Category Protein
Target ANG
Alternative Names Angiogenin;RNASE5; RAA1; Angiogenin, Ribonuclease, RNase A Family, 5; Ribonuclease A Family Member 5; Ribonuclease 5; RNase 5; Epididymis Luminal Protein 168; Ribonuclease A A1; EC 3.1.27.-; EC 3.1.27; HEL168; RNASE4; ALS9
Gene ID 283
UniProt ID P03950
Target Overview The protein encoded by this gene is a member of the RNase A superfamily though it has relatively weak ribonucleolytic activity. This protein is a potent mediator of new blood vessel formation and thus, in addition to the name RNase5, is commonly called angiogenin. This protein induces angiogenesis after binding to actin on the surface of endothelial cells. This protein also accumulates at the nucleolus where it stimulates ribosomal transcription. Under stress conditions this protein translocates to the cytosol where it hydrolyzes cellular tRNAs and influences protein synthesis. A signal peptide is cleaved from the precursor protein to produce a mature protein which contains a nuclear localization signal, a cell binding motif, and a catalytic domain. This protein has been shown to be both neurotrophic and neuroprotective and the mature protein has antimicrobial activity against some bacteria and fungi, including S. pneumoniae and C. albicans. Due to its effect on rRNA production and angiogenesis this gene plays important roles in cell growth and tumor progression. Mutations in this gene are associated with progression of amyotrophic lateral sclerosis (ALS). This gene and the neighboring RNase4 gene share promoters and 5' exons though each gene then splices to a distinct 3' exon containing the complete coding region of each gene. Alternative splicing results in multiple transcript variants encoding the same protein.
Type DNA
Species Reactivity Human
Length <50 nt
Affinity (Kd) 1-50 nM
Binding Conditions/Buffer 10 mM Tris-HCl, 15 mM Na+, pH = 7.4,
GC Content 46.81%
Molecular Weight 13849 g/mole
nmoles/OD260 2.163

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