Anti-Human C3 Aptamer(Cat#: CTMM-0124-RJ16)
This product is an aptamer which binds to Human C3 with an affinity of 1-50 nM.
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Summary
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Specifications
| Target Category |
Protein |
| Target |
C3 |
| Alternative Names |
Complement C3; CPAMD1; ARMD9; C3 And PZP-Like Alpha-2-Macroglobulin Domain-Containing Protein 1; Complement Component C3a; Complement Component C3b; Complement Component 3; C3a Anaphylatoxin; Prepro-C3; C3a; C3b; Epididymis Secretory Sperm Binding Protein Li 62p; Acylation-Stimulating Protein Cleavage Product; HEL-S-62p; AHUS5; ASP; C3A; C3B; C3 |
| Gene ID |
718 |
| UniProt ID |
P01024 |
| Target Overview |
Complement component C3 plays a central role in the activation of complement system. Its activation is required for both classical and alternative complement activation pathways. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that form the mature protein, which is then further processed to generate numerous peptide products. The C3a peptide, also known as the C3a anaphylatoxin, modulates inflammation and possesses antimicrobial activity. Mutations in this gene are associated with atypical hemolytic uremic syndrome and age-related macular degeneration in human patients. |
| Chemical Modification |
2'-fluoro pyrimidines |
| Type |
RNA |
| Species Reactivity |
Human; Mouse |
| Length |
50-100 nt |
| Affinity (Kd) |
1-50 nM |
| Binding Conditions/Buffer |
20 mM HEPES, 150 mM NaCl, and 10 mM MgCl2, pH 7.4 |
| GC Content |
56.14% |
| Molecular Weight |
16696.5 g/mole |
| nmoles/OD260 |
1.726 |
For Research Use Only. Not for Diagnostic or Therapeutic Applications.
