Native Rabbit Complement C3 Protein(Cat#: CTMM-0123-MM31)
This product is a 185 kDa native rabbit C3 protein isolated from normal rabbit serum. It is availible for Functional Assays.
Summary
Related Products & Services
Specifications
| Specie Reactivity |
Rabbit |
| Target |
C3 |
| Molecule Mass |
185 kDa |
| Purity |
>85% determined by SDS-PAGE |
| Formulation |
10 mM sodium phosphate, 145 mM NaCl, pH 7.2 |
| Applications |
Functional Assays |
| Product Form |
Frozen liquid |
| Storage |
Store at -80°C. Avoid freeze-thaw cycles. |
Protein Information
| Introduction |
C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates.
Derived from proteolytic degradation of complement C3, C3a anaphylatoxin is a mediator of local inflammatory process. In chronic inflammation, acts as a chemoattractant for neutrophils (By similarity). It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes.
[C3-beta-c]: Acts as a chemoattractant for neutrophils in chronic inflammation.
[Acylation stimulating protein]: adipogenic hormone that stimulates triglyceride (TG) synthesis and glucose transport in adipocytes, regulating fat storage and playing a role in postprandial TG clearance. Appears to stimulate TG synthesis via activation of the PLC, MAPK and AKT signaling pathways. Ligand for C5AR2. Promotes the phosphorylation, ARRB2-mediated internalization and recycling of C5AR2. |
| Alternative Names |
Complement C3; Complement Component 3; Complement Component C3; C3 |
| Gene ID |
12266 |
| UniProt ID |
P01027 |
For Research Use Only. Not for Diagnostic or Therapeutic Applications.
