Anti-Human ITGAV Aptamer(Cat#: CTMM-0124-LH17)

This product is an aptamer which binds to Human ITGAV domain with an affinity of 200-1000 nM.

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Specifications
Target Category Protein
Target ITGAV
Alternative Names Integrin Subunit Alpha V; CD51; MSK8; VNRA; VTNR; Integrin, Alpha V (Vitronectin Receptor, Alpha Polypeptide, Antigen CD51); Antigen Identified By Monoclonal Antibody L230; Vitronectin Receptor Subunit Alpha; Vitronectin Receptor; Integrin Alpha-V; Integrin AlphaVbeta3; Integrin, Alpha V; CD51 Antigen
Gene ID 3685
UniProt ID P06756
Target Overview The product of this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha subunit and a beta subunit that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha V subunit. This subunit associates with beta 1, beta 3, beta 5, beta 6 and beta 8 subunits. The heterodimer consisting of alpha V and beta 3 subunits is also known as the vitronectin receptor. This integrin may regulate angiogenesis and cancer progression. Alternative splicing results in multiple transcript variants. Note that the integrin alpha 5 and integrin alpha V subunits are encoded by distinct genes.
Type RNA
Species Reactivity Human
Length 50-100 nt
Affinity (Kd) 200-1000 nM
Binding Conditions/Buffer 145 mM NaCl, 5.4 mM KCl, 0.8 mM MgCl2, 1.8 mM CaCl2, 20 mM Tris-HCl, pH=7.6
GC Content 50.00%
Molecular Weight 24630 g/mole
nmoles/OD260 1.183

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