This product is an unconjugated anti-Human Collectin-11 Monoclonal antibody (CTJS-573) generated from the Mouse. The antibody can be used for WB, IF, ELISA.
Clonality | Monoclonal |
Clone | CTJS-573 |
Host Animal | Mouse |
Isotype | IgG |
Epitope | The carbohydrate recognition domain (CRD) |
Immunogen | Recombinant human Collectin 11 expressed in E. coli., a.a. 107-271 |
Species Reactivity | Human; Mouse; Rat; Hamster |
Applications | WB; IF; ELISA |
Application Notes | WB: 1:500-1:1,000 IF: 1:500 The optimal working dilutions should be determined by the end user. |
Specificity | This antibody reacts with Human, Mouse, Rat, and Hamster Collectin-11. |
Purity | ≥95% as determined by SDS-PAGE |
Conjugation | Unconjugated |
Format | Liquid |
Size | 100 µg |
Storage | Store at 4°C for short term. Store at -20°C for long term. Avoid freeze-thaw cycle. |
Type | Primary Antibody |
Target Name | Collectin-11 |
Alternative Names | Collectin Subfamily Member 11; Collectin Kidney Protein 1; Collectin K1; Collectin-11; CL-K1; Collectin Sub-Family Member 11; CL-K1-Iia; CL-K1-Iib; CL-K1-II; COLEC11; 3MC2; CLK1 |
Gene ID | 78989 |
UniProt ID | Q9BWP8 |
Introduction | Collectin-11 (CL-11) is a lectin that plays a role in innate immunity, apoptosis and embryogenesis. Calcium-dependent lectin that binds self and non-self glycoproteins presenting high mannose oligosaccharides with at least one terminal alpha-1,2-linked mannose epitope. Primarily recognizes the terminal disaccharide of the glycan. Also recognizes a subset of fucosylated glycans and lipopolysaccharides. Plays a role in innate immunity through its ability to bind non-self sugars presented by microorganisms and to activate the complement through the recruitment of MAPS1. Also plays a role in apoptosis through its ability to bind in a calcium-independent manner the DNA present at the surface of apoptotic cells and to activate the complement in response to this binding. Finally, plays a role in development, probably serving as a guidance cue during the migration of neural crest cells and other cell types during embryogenesis. |