This product is an unconjugated anti-Human CR1 Monoclonal antibody (CTJS-264) generated from the Mouse. The antibody can be used for WB; ELISA; FC; IF; IHC; IP.
Clonality | Monoclonal |
Clone | CTJS-264 |
Host Animal | Mouse |
Isotype | IgG1 Kappa |
Immunogen | Intact human monocytes were used as immunogen to generate the CD35 antibody (Hogg et al, 1984). |
Species Reactivity | Human; Primate |
Applications | WB; ELISA; FC; IF; IHC; IP |
Application Notes | WB: 0.5-1µg/mL ELISA: 1-5µg/mL FC: 0.5-1ug/10^6 cells IF: 1-2µg/mL IHC: 0.5-1µg/mL IP: 1-2ug/500ug protein lysate The optimal working dilutions should be determined by the end user. |
Specificity | This antibody reacts with Human, Primate CR1. |
Purity | ≥95% as determined by SDS-PAGE |
Format | Liquid |
Size | 20; 100 µg |
Storage | 4°C |
Type | Primary Antibody |
Target Name | CR1 |
Alternative Names | Complement C3b/C4b Receptor 1 (Knops Blood Group); C3b/C4b Receptor; CD35 Antigen; Knops Blood Group Antigen; Complement Receptor 1; C3-Binding Protein; Complement Receptor Type 1; KN; C3BR; C4BR; CD35; Cr1; C3DR; CD21; Cr-1; Cr-2 |
Gene ID | 1378 |
UniProt ID | P17927 |
Introduction | Complement receptor 1 (CR1) also known as CD35, cluster of differentiation 35, is a protein that in humans is encoded by the CR1 gene. CR1 can act as a negative regulator of the complement cascade, mediate immune adherence and phagocytosis and inhibit both the classic and alternative pathways. Complement receptor 2 (CR2), also known as CD21, cluster of differentiation 21, is a protein that in humans is encoded by the CR2 gene. CR2 is involved in the complement system. It binds to iC3b (inactive derivative of C3b), C3dg, or C3d. B cells have CR2 receptors on their surfaces, allowing the complement system to play a role in B-cell activation and maturation. |