Recombinant Human Complement Factor H Protein-GST tag(Cat#: CTP-112)
This product is a 75.02 kDa recombinant human Complement Factor H protein with a GST tag at N-terminal expressed in the Wheat Germ. It is available for WB, ELISA, PA, AP.
Summary
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Specifications
| Expressed Host |
Wheat Germ (in vitro) |
| Specie Reactivity |
Human |
| Target |
Factor H |
| Molecule Mass |
75.02 kDa |
| Purity |
>80% by SDS-PAGE and Coomassie Blue staining |
| Formulation |
50 mM Tris-HCI, 10 mM reduced Glutathione, pH 8.0 |
| Applications |
WB; ELISA; PA; AP |
| Product Form |
Liquid |
| Storage |
Store at -20/-80°C. Aliquot to avoid repeated freezing and thawing. |
Protein Information
| Introduction |
Complement factor H plays an essential role in maintaining a well-balanced immune response by modulating complement activation. Acts as a soluble inhibitor of complement, where its binding to self markers such as glycan structures prevents complement activation and amplification on cell surfaces. Accelerates the decay of the complement alternative pathway (AP) C3 convertase C3bBb, thus preventing local formation of more C3b, the central player of the complement amplification loop. As a cofactor of the serine protease factor I, CFH also regulates proteolytic degradation of already-deposited C3b. In addition, mediates several cellular responses through interaction with specific receptors. For example, interacts with CR3/ITGAM receptor and thereby mediates the adhesion of human neutrophils to different pathogens. In turn, these pathogens are phagocytosed and destroyed. |
| Alternative Names |
adrenomedullin binding protein; age-related maculopathy susceptibility 1; AHUS1; AMBP1; ARMD4; ARMS1; beta-1H; beta-1-H-globulin; beta-1-H-globulin; CFH; CFHL3; Complement Factor H; factor H; factor H-like 1; FH; FHL1; H factor 1 (complement); H factor 1; H factor 2 (complement); HF; HF1; HF1ARMS1; HF2; HUS |
| Gene ID |
3075 |
| UniProt ID |
P08603 |
For Research Use Only. Not for Diagnostic or Therapeutic Applications.
