Recombinant Mouse Complement C3 Protein-N-terminal His Tag(Cat#: CTP-512)
This product is a recombinant mouse C3 protein with a N-terminal His Tag tag expressed in the E.coli. It is availible for WB, ELISA, IP.
Summary
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Specifications
| Expressed Host |
E.coli |
| Specie Reactivity |
Mouse |
| Target |
C3 |
| Purity |
>97 % determined by SDS-PAGE |
| Endotoxin |
<1.0EU per 1µg (determined by the LAL method) |
| Formulation |
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300 |
| Applications |
WB; ELISA; IP |
| Product Form |
Lyophilized |
| Storage |
Store at -20°C/-80°C. Avoid freeze-thaw cycles. |
Protein Information
| Introduction |
C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates.
Derived from proteolytic degradation of complement C3, C3a anaphylatoxin is a mediator of local inflammatory process. In chronic inflammation, acts as a chemoattractant for neutrophils (By similarity). It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes.
[C3-beta-c]: Acts as a chemoattractant for neutrophils in chronic inflammation.
[Acylation stimulating protein]: adipogenic hormone that stimulates triglyceride (TG) synthesis and glucose transport in adipocytes, regulating fat storage and playing a role in postprandial TG clearance. Appears to stimulate TG synthesis via activation of the PLC, MAPK and AKT signaling pathways. Ligand for C5AR2. Promotes the phosphorylation, ARRB2-mediated internalization and recycling of C5AR2. |
| Alternative Names |
Complement C3; Complement Component 3; Complement Component C3; C3 |
| Gene ID |
12266 |
| UniProt ID |
P01027 |
For Research Use Only. Not for Diagnostic or Therapeutic Applications.
