Magic™ In Vitro Cell-based Adrenergic Receptor Functional Assay Service

Adrenergic Receptors with Prospect

Adrenergic receptors (ARs), or adrenoceptors, are a group of GPCRs distributed throughout every part of the body. They play a vital role in regulating diverse physiological processes in humans. Recent research indicates that therapeutic targeting by modification of the adrenergic system could function as an effective systemic therapy for cancers, particularly bladder cancer. Consequently, comprehending the function of adrenergic receptors has great significance for its application in drug development of cancer therapy.

Fig.1 Adrenergic receptors-mediated signaling in endothelial and cancer cells.¹

Our Magic™ In Vitro Cell-based Adrenergic Receptor Functional Assay Service

Creative Biolabs provides rapid and effective Magic™ in vitro cell-based adrenergic receptor functional assay service to support global customers' diverse needs. Our Magic™ in vitro cell-based adrenergic receptor functional assay services are conducted by exposing samples to ligands in a concentration gradient and then measuring calcium flux and β-arrestin recruitment of downstream signaling. We provide a wide range of services that include, but are not restricted to, the examination of signaling pathways, which may include the recruitment of β-arrestin and calcium flux-mediated G protein activation. Creative Biolabs is dedicated to presenting the desirable outcomes for global customers.

Fig.2 Adrenergic receptor signaling in neuroimmune communication.²

The breadth of Our Magic™ In Vitro Cell-based Adrenergic Receptor Functional Assay Service

Fig.3 The workflow of our Magic™ in vitro cell-based adrenergic receptor functional assay service.

Data Speaking

Representative data 1: Gαs coupling is required for β2AR-mediated ERK activation.

Fig.4 The role of Gαs in β2AR-mediated ERK phosphorylation.³

Work with Creative Biolabs

Feel free to get in touch with us if you have any questions concerning our Magic™ in vitro cell-based adrenergic receptor functional assay service. We are eager to begin collaborating with customers from all over the world.

Frequently Asked Questions

Q1: What is the difference between epinephrine & adrenaline?

A1: Epinephrine functions as both a neurotransmitter and a hormone, however, it is mostly a hormone. Adrenaline, or epinephrine, plays a significant role in the body's fight-or-flight response. It is also used to treat a variety of life-threatening illnesses as a medicine.

References

1. Xanthopoulos, Athanasios, et al. "A systematic review on the role of adrenergic receptors in angiogenesis regulation in health and disease." International Journal of Translational Medicine 1.3 (2021): 353-365.
2. Chhatar, Sushanta, and Girdhari Lal. "Role of adrenergic receptor signaling in neuroimmune communication." Current Research in Immunology 2 (2021): 202-217.
3. O'Hayre, Morgan, et al. "Genetic evidence that β-arrestins are dispensable for the initiation of β2-adrenergic receptor signaling to ERK." Science signaling 10.484 (2017): eaal3395.

For Research Use Only.