Pituitary adenylate-cyclase-activating polypeptide receptor (PACAP receptor), a subtype of GPCR, meditates PACAP signal transmission. At the periphery, they regulate hormone release from the anterior pituitary gland, immunosuppression, and other processes. In the central nervous system, PACAP receptors not only meditate the transmission of neurotransmitters but also protect neurons. This receptor is implicated in several biological processes. In general, the function diversity of PACAP receptors sheds light on disease therapy. Accordingly, an understanding of their function mechanism may boost the development of new therapeutic drugs.
Fig.1 The action of PACAP receptors in the regulation of food intake.1
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Fig.2 PACAP and its receptor in the cellular microenvironment of hypoxic niches.2
Creative Biolabs' Magic™ in vitro cell-based PACAP receptor functional assay service surpasses the constraints of conventional PACAP receptor functional assays and offers significant benefits to our global customers. At Creative Biolabs, you will obtain the idealist outcomes for your projects in a short period.
Representative data 1: These results demonstrate for the first time that PACAP and VIP derivatives (PACAP-TAT and VIP-TAT) applied topically reduce ischemic retinal degeneration through the PAC1 receptor, which demonstrated the traversing ability of the PACAP/VIP tagged with cell-penetrating peptide TAT were enhanced.
Fig.3 cAMP accumulation induced by ligands activates PAC1-R.3
Representative data 2: The findings suggest that in contrast to the GLP-1R ECD (Extracellular domain), which plays a crucial role in receptor activation, the PAC1R ECD seems to operate as an affinity trap in our study, highlighting the functional variety of the ECDs in class B GPCRs.
Fig.4 Functional characterization of mutant PAC1 receptors.4
As an industry pioneer, Creative Biolabs strives to maintain progress and drive continuous innovation in existing technologies, always taking into account valuable feedback from our global customer base. For more information about our receptor Magic™ in vitro cell-based PACAP receptor functional assay service, please feel free to contact us. Our experienced research team is eager to work with you.
References
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