As a pioneer and the undisputed global leader in antibody function analysis, Creative Biolabs is proud to offer our clients a series of target binding-based function analysis and characterization services with the best quality and most competitive price. Here, we are happy to introduce our professional service of GPCR-targeted functional assays with our diverse technologies.
G-protein coupled receptors (GPCRs) are one of the largest and the most versatile superfamily among cell surface receptors. Studies have shown that different GPCRs interact with different types of ligands, including photons, ions, biogenic amines, peptide, and non-peptide neurotransmitters, hormones, growth factors, and lipids. Consequently, GPCR signaling is involved in vision, taste, olfaction, sympathetic and parasympathetic nervous functions, metabolism, and immune regulation, indicating that GPCRs are very important therapeutic targets for various diseases. Recently, GPCRs have been treated as valuable molecular targets for drug discovery due to their potential in facilitating the development of novel therapeutics. Therefore, there is an urgent to design and implement numerous GPCR-targeted functional assays to identify novel drug candidates.
Fig.1 Diagrammatic representation of how G protein inhibition can bias GPCR signaling. (Campbell, 2018)
With years of experience and professional scientists, Creative Biolabs has successfully established an advanced technology platform to speed up your GPCR drug discovery. Our experienced scientists are happy to provide a comprehensive list of services to help with your GPCR study. The GPCR-targeted functional assays we can offer include both GPCR screening and GPCR stable cell lines development.
Aided by top technology, we provide a full package of GPCR screening services covering all GPCR classes. We can help global clients design customized GPCR analytical scheme based on specific requirements and preliminary results. Furthermore, we provide assay systems which cover calcium flux, cAMP level, and reporter assay for our customers to carry out high-throughput screening (HTS).
Stable cell lines expressing recombinant targets such as ion channels and GPCRs are widely used in a number of research applications, such as drug discovery screening and safety assessment. The generation of stable cell lines is a time-consuming and expensive process. Creative Biolabs has generated more than 200 functionally validated custom cell lines with particular focus on over-expression of membrane proteins. Our top technology platform enables us to offer high-quality services at significant cost savings to our clients.
In addition, Creative Biolabs is committed to providing several custom Magic™ in vitro cell-based GPCR functional assay services for global customers to speed up drug development. Our Magic™ in vitro cell-based GPCR functional assay services featured multiple second messenger pathways and measured with the various second messengers' readouts according to the natural pathways of GPCRs.
With our versatile and robust technology platforms and seasoned team of experts, Creative Biolabs is the right choice to deliver holistic and reliable GPCR-targeted functional assays. For more detailed information, please feel free to contact us or directly send us an inquiry.
Reference
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