Bombesin receptors are a subfamily of G protein-coupled receptors and consist of three different subtypes: BB1, BB2, and BB3. The central nervous system and gastrointestinal tract exhibit a wide distribution of these receptors, which have numerous physiological and pathologic effects. What's more, bombesin receptors are among the most overexpressed receptors in cancers and have drawn widespread attention to their role in tumor growth and development. Thus, identifying the function of bombesin receptors will boost their application in cancer therapy.
Fig.1 Targeting of gastrin-releasing peptide receptor (Bombesin receptors).1
Creative Biolabs provides a robust and effective Magic™ in vitro cell-based bombesin receptor functional assay service to satisfy global customers' diverse needs. The main idea of our Magic™ in vitro cell-based bombesin receptor functional assay service is to measure the calcium flux in response to cellular response triggered by the reaction of bombesin receptors with their ligands. As a leading GPCR functional assay provider, Creative Biolabs has years of experience and expertise in this field. At Creative Biolabs, you'll achieve ideal results at an affordable price while speeding up your project's progress.
Fig.2 The workflow of our Magic™ in vitro cell-based bombesin receptor functional assay service.
Multiple types of cell lines
We provide numerous range of stable expressing cell lines including but not limited to human leukemia Jurkat T cells, human melanoma A375 cell lines, MCF-7 human breast cancer cells, CHO cell lines, etc., to choose from for global customers' projects.
Reliable and reputable experiment systems
Our experimental system has years of project experience and is continually being optimized as technology advances. Together with straightforward experimental procedures, we have complete confidence that we will achieve desirable outcomes for global customers.
Competent research team
Our research team features a group of specialists with extensive professional training, practical experience, and expertise, which together with state-of-the-art technologies make us confident in presenting high-quality data to global customers.
Comprehensive customized services
We offer a comprehensive customized Magic™ in vitro cell-based bombesin receptor functional assay service. Our services cover all aspects, from sample preparation to data presentation, using the latest and most advanced technical solutions available.
Representative Data
Representative data 1: These data support the hypothesis that cBRS3 may act as a receptor for both cGRP and cNMB. Furthermore, the findings support a functional link between the aforementioned three receptors and the MAPK/ERK signaling cascade.
Fig.3 The EC50 values of chicken GRPR, BRS3, and NMBR for function characterization.2
Fig.4 The results of luciferase reporter assay in function characterization of chicken NMBR, BRS3, and GRPR.2
If you are intrigued by our Magic™ in vitro cell-based bombesin receptor functional assay service, feel free to reach out to us without delay. Our experienced scientists are eager to fulfill even the most challenging requirements and deliver the best answer for global customer satisfaction.
References
For Research Use Only.
