Online Inquiry

For Lab Research Use Only, Not for Human or Animal Therapeutic Use.

  • Verification code
    Click image to refresh the verification code.

Custom mRNA Synthesis

Since its foundation, Creative Biolabs has been the industry leader in custom mRNA synthesis for research and clinical applications. Our scientists and staff have over 10 years of experience in mRNA oligos synthesis and modifications, which enables us to provide high-quality mRNA synthesis with excellent purity and biological activity.

mRNA Synthesis

mRNA is a single-stranded RNA molecule that is complementary to one of the DNA strands of a gene. Synthetic mRNAs have been used to study protein-mediated mRNA recognition, mRNA export and translation, and mutation effects in protein-coding genes. Recently, mRNA-based drugs have been developed for use in prophylactic vaccines, cancer immunotherapy, and the treatment of other diseases. They take advantage of normal biological processes to express proteins and produce a desired therapeutic effect. However, the limitation of chemically synthesized longer mRNA at large quantity continues to be a synthesis bottleneck. In contrast, template-directed mRNA synthesis by in vitro transcription can solve this problem and is considered an effective strategy for mRNA synthesis.

Custom mRNA Synthesis Services

Creative Biolabs has a wide range of experience in supplying clients with mRNA synthesis at the appropriate quality level for each project stage. We manufacture research-grade or GMP-grade mRNAs and provide tailored synthesis at milligram to multigram scales, with lengths ranging from a few hundred nucleotides to more than 10 kilobases. Through research-grade or GMP-grade mRNA synthesis services, we can support your project from discovery to clinical development. We offer a full range of mRNA synthesis services to fit your project requirements.

Our service includes:

The Workflow of Custom mRNA Synthesis:

Custom mRNA Synthesis

For all customized mRNAs, we offer different scales and modifications:

Scales & modifications
Size & Scale
  • All mRNAs are available from a few hundred up to several thousand bases
  • Up to gram scales of mRNA and long RNA (multiple kilobases), other scales are available upon request
Synthesis quality
  • Research grade (in compliance with ISO 13485)
  • GMP-grade (in compliance with FDA 21 CFR Part 820)
  • A wide variety of modifications include 5’ terminal modifications with cap, internal modification such as 5-methylcytidine or pseudouridine and 3’ modification such as poly-A tail
Additional QC's
  • Sterility
  • Bioburden controls

Creative Biolabs’ custom mRNA synthesis services exhibit some exceptional advantages including:

Delivery Specifications

Turnaround time


All our mRNA oligos are highly purified and checked for their quality. For large-scale orders or for special purity, yield, or formulation of your oligos, please contact us and we will be happy to discuss your project needs.

For Lab Research Use Only, Not for Human or Animal Therapeutic Use.

Interested in our expertise?

Contact us for more information

Get free consultations


  • Tel:
  • Email:


Easy access to products and services you need from our library via powerful searching tools

Enter your email here to subscribe.


Follow us on

For Lab Research Use Only, Not for Human or Animal Therapeutic Use.

Copyright © 2021 Creative Biolabs. All Rights Reserved.