Human Complement Factor H Autoantibody (IgG) ELISA Kit(Cat#: CTK-504)
This product is an ELISA kit for the determination of Human Complement Factor H Autoantibody (IgG) in the samples of Serum. It is highly sensitive and available for the detection of Human Complement Factor H Autoantibody (IgG) as low as 0.6 AU/mL.
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Specifications
| Assay Type |
Competition ELISA |
| Sensitivity |
0.6 AU/mL (4 -250 AU/mL) |
| Pack Size |
96 tests |
| Species Reactivity |
Human |
| Target |
Factor H |
| Applications |
ELISA |
| Storage |
4°C in the dark. |
Information
| Introduction |
Complement factor H plays an essential role in maintaining a well-balanced immune response by modulating complement activation. Acts as a soluble inhibitor of complement, where its binding to self markers such as glycan structures prevents complement activation and amplification on cell surfaces. Accelerates the decay of the complement alternative pathway (AP) C3 convertase C3bBb, thus preventing local formation of more C3b, the central player of the complement amplification loop. As a cofactor of the serine protease factor I, CFH also regulates proteolytic degradation of already-deposited C3b. In addition, mediates several cellular responses through interaction with specific receptors. For example, interacts with CR3/ITGAM receptor and thereby mediates the adhesion of human neutrophils to different pathogens. In turn, these pathogens are phagocytosed and destroyed. |
Customer Review
The kit's protocol is straightforward and the results are consistently reliable
Excellent
We appreciate the high sensitivity and specificity, which have allowed us to detect even low levels of autoantibodies. The included reagents are of excellent quality, and the detailed manual ensures that even those new to ELISA can achieve great results.
This one stands out for its exceptional accuracy and reproducibility
Excellent
The ELISA kit provided clear and consistent data, crucial for our publication. The kit's components are well-packaged and easy to use. The results were easy to interpret, and we experienced minimal variation between assays.
This ELISA kit has been instrumental in advancing our understanding of autoimmune responses involving complement factor H
Excellent
The kit includes all necessary reagents and a comprehensive protocol, making the process seamless. The results were consistent across multiple samples, which is critical for our longitudinal studies. We will definitely continue using this kit.
The assay is both sensitive and specific, providing us with reliable data
Excellent
We have been very satisfied with the performance of the kit. The clear instructions and well-organized components made the setup straightforward, even for our junior lab members. The consistency of the results across different batches was particularly impressive.
Highly recommended
Excellent
The assay's sensitivity allowed us to detect low levels of autoantibodies that we previously missed with other kits. The comprehensive manual and high-quality reagents made the entire process smooth and efficient. The consistency and reliability of the results have given us great confidence in our findings.
For Research Use Only. Not for Diagnostic or Therapeutic Applications.
