Native Human C3a des Arg Protein(Cat#: CTP-254)
This product is a natural full-length human complement C3a des Arg protein derived from healthy blood donors.
Summary
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Specifications
| Specie Reactivity |
Human |
| Target |
C3 |
| Purity |
≥90% determined by SDS-PAGE |
| Endotoxin |
<1.0EU per 1µg (determined by the LAL method) |
| Formulation |
PBS, pH 7.2 |
| Product Form |
Liquid |
| Storage |
Store at -80°C. Avoid freeze-thaw cycles. |
Protein Information
| Introduction |
C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates. Derived from proteolytic degradation of complement C3, C3a anaphylatoxin is a mediator of local inflammatory process. In chronic inflammation, acts as a chemoattractant for neutrophils. It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes.
C3a itself is very short-lived and in serum is cleaved rapidly into the more stable C3a-desArg (also called acylation stimulating protein, ASP). Expression of C3aR on haematopoietic stem/progenitor cells has been shown to promote the trafficking/homing of these cells to the BM. Engagement of C3aR on DCs and T cells has been shown to up-regulate these cell functions. |
| Alternative Names |
C3a desArg; C3a des-Arg |
| Gene ID |
718 |
| UniProt ID |
P01024 |
For Research Use Only. Not for Diagnostic or Therapeutic Applications.
