Native Human Complement C4a Protein(Cat#: CTP-527)
This product is a 8.8 kDa native human C4a protein isolated from normal human serum. It is availible for Functional Assays.
Summary
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Specifications
| Specie Reactivity |
Human |
| Target |
C4A |
| Molecule Mass |
8.8 kDa |
| Purity |
>95% determined by SDS-PAGE |
| Endotoxin |
<1.0EU per 1µg (determined by the LAL method) |
| Formulation |
HEPES buffered saline, pH 7.2 |
| Applications |
Functional Assays |
| Product Form |
Frozen liquid |
| Storage |
Store at -20°C/-80°C. Avoid freeze-thaw cycles. |
Protein Information
| Introduction |
Non-enzymatic component of C3 and C5 convertases and thus essential for the propagation of the classical complement pathway. Covalently binds to immunoglobulins and immune complexes and enhances the solubilization of immune aggregates and the clearance of IC through CR1 on erythrocytes. C4A isotype is responsible for effective binding to form amide bonds with immune aggregates or protein antigens, while C4B isotype catalyzes the transacylation of the thioester carbonyl group to form ester bonds with carbohydrate antigens.
Derived from proteolytic degradation of complement C4, C4a anaphylatoxin is a mediator of local inflammatory process. It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes. |
| Alternative Names |
omplement C4A (Rodgers Blood Group)
C3 And PZP-Like Alpha-2-Macroglobulin Domain-Containing Protein
Complement Component 4A (Rodgers Blood Group)
Acidic Complement C4
Complement C4-A
C4A4
C4A6
C4S
MHC Class III Region Complement
Complement Component 4A
Rodgers Form Of C4
C4A Anaphylatoxin
C4AD
C4A |
| Gene ID |
720 |
| UniProt ID |
P0C0L4 |
For Research Use Only. Not for Diagnostic or Therapeutic Applications.
