Native Human Complement C4b Protein(Cat#: CTP-533)
This product is a 195 kDa native human C4b protein isolated from normal human serum. It is availible for Functional Assays.
Summary
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Specifications
| Specie Reactivity |
Human |
| Target |
C4B |
| Molecule Mass |
195 kDa |
| Purity |
>90 % determined by SDS-PAGE |
| Endotoxin |
<1.0EU per 1µg (determined by the LAL method) |
| Formulation |
10 mM Sodium phosphate, 145 mM NaCl, pH 7.3 |
| Applications |
Functional Assays |
| Product Form |
Frozen liquid |
| Storage |
Store at -20°C/-80°C. Avoid freeze-thaw cycles. |
Protein Information
| Introduction |
Non-enzymatic component of the C3 and C5 convertases and thus essential for the propagation of the classical complement pathway. Covalently binds to immunoglobulins and immune complexes and enhances the solubilization of immune aggregates and the clearance of IC through CR1 on erythrocytes. C4A isotype is responsible for effective binding to form amide bonds with immune aggregates or protein antigens, while C4B isotype catalyzes the transacylation of the thioester carbonyl group to form ester bonds with carbohydrate antigens.
Derived from proteolytic degradation of complement C4, C4a anaphylatoxin is a mediator of local inflammatory process. It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes. |
| Alternative Names |
Complement C4B (Chido Blood Group); C3 And PZP-Like Alpha-2-Macroglobulin Domain-Containing Protein 3; Complement Component 4B (Chido Blood Group); Basic Complement C4; Complement C4-B; Complement Component 4B; Chido Form Of C4; Complement C4B1a; C4B |
| Gene ID |
721 |
| UniProt ID |
P0C0L5 |
For Research Use Only. Not for Diagnostic or Therapeutic Applications.
