Rabbit Anti-Human Complement C4B Polyclonal Antibody(Cat#: CTA-312)
This product is an unconjugated anti-Human Complement C4B Polyclonal antibody generated from the Rabbit. The antibody can be used for WB.
Summary
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Specifications
| Clonality |
Polyclonal |
| Host Animal |
Rabbit |
| Isotype |
IgG |
| Immunogen |
Carrier-protein conjugated synthetic peptide encompassing a sequence within the C-terminus region of human C4B. The exact sequence is proprietary. |
| Species Reactivity |
Human |
| Applications |
WB |
| Application Notes |
WB: 1:500-1:3000
The optimal working dilutions should be determined by the end user. |
| Specificity |
This antibody reacts with Human complement C4B. |
| Purity |
≥95% as determined by SDS-PAGE |
| Format |
Liquid |
| Size |
100 µL |
| Storage |
Aliquot and store at -20°C or -80°C. Avoid freeze-thaw cycles. |
| Type |
Primary Antibody |
Target
| Target Name |
C4b |
| Alternative Names |
Complement C4B (Chido Blood Group); C3 And PZP-Like Alpha-2-Macroglobulin Domain-Containing Protein 3; Complement Component 4B (Chido Blood Group); Basic Complement C4; Complement Component 4B; Chido Form Of C4; Complement C4B1a; Complement C4-B; CH; C4F; CO4; C4B1; C4B2; C4B3; C4B5; C4BD; C4B12; C4B_2; CPAMD3 |
| Gene ID |
721 |
| UniProt ID |
P0C0L5 |
Information
| Introduction |
Complement component 4B (Chido blood group) is a protein that in humans is encoded by the C4B gene. This gene encodes the basic form of complement factor 4, part of the classical activation pathway. The protein is expressed as a single chain precursor which is proteolytically cleaved into a trimer of alpha, beta, and gamma chains prior to secretion. The trimer provides a surface for interaction between the antigen-antibody complex and other complement components. The alpha chain may be cleaved to release C4 anaphylatoxin, a mediator of local inflammation. Deficiency of this protein is associated with systemic lupus erythematosus. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. Varying haplotypes of this gene cluster exist, such that individuals may have 1, 2, or 3 copies of this gene. In addition, this gene exists as a long form and a short form due to the presence or absence of a 6.4 kb endogenous HERV-K retrovirus in intron 9. |
For Research Use Only. Not for Diagnostic or Therapeutic Applications.
