Rat Anti-Human CD18 Monoclonal Antibody (TJL-176) [Allophycocyanin](Cat#: CTMM-0322-JL1763)

This product is a Allophycocyanin conjugated anti-Human Complement CD18 Monoclonal antibody (TJL-176) generated from the Rat. The antibody can be used for Flow.

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Specifications
Clonality Monoclonal
Clone TJL-176
Host Animal Rat
Isotype IgG2b
Immunogen Human Complement C1q
Species Reactivity Human
Applications Flow
Application Notes Flow: 1:50-1:100
Specificity This antibody reacts with Human Complement CD18.
Purity ≥95% as determined by SDS-PAGE
Conjugation Allophycocyanin
Format Liquid
Size 100 ul
Storage Store in dark at 4°C. Do Not Freeze.
Type Primary Antibody
Target
Target Name CD18
Alternative Names Cell surface adhesion glycoproteins LFA-1/CR3/p150,95 subunit beta; Complement receptor C3 subunit beta; CD_antigen: CD18; Leukocyte Cell Adhesion Molecule CD18; Complement Receptor C3 Beta-Subunit; Macrophage Antigen 1 (Mac-1) Beta Subunit); LAD; CD18; MF17; MFI7; LCAMB; LFA-1; MAC-1
Gene ID 3689
UniProt ID P05107
Information
Introduction In molecular biology, CD18 (Integrin beta chain-2) is an integrin beta chain protein that is encoded by the ITGB2 gene in humans. Upon binding with one of a number of alpha chains, CD18 is capable of forming multiple heterodimers, which play significant roles in cellular adhesion and cell surface signaling, as well as important roles in immune responses. CD18 also exists in soluble, ligand binding forms. Deficiencies in CD18 expression can lead to adhesion defects in circulating white blood cells in humans, reducing the immune system's ability to fight off foreign invaders. The ITGB2 protein product is CD18. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain, and are crucial for cells to be able to efficiently bind to the extracellular matrix. This is especially important for neutrophils, as cellular adhesion plays a large role in extravasation from the blood vessels. A given chain may combine with multiple partners resulting in different integrins.
For Research Use Only. Not for Diagnostic or Therapeutic Applications.
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