Recombinant Anti-CCR3 x Anti-CD300 Bispecific Antibody (Fab-scFv-Fc) (FABVC-028)

Recombinant Anti-CCR3 x Anti-CD300 Bispecific Antibody (Fab-scFv-Fc) requires expression of three polypeptide chains, encoding two heavy chains (Fc-containing chains) and one light chain, respectively. The Fab of anti-CCR3 antibody variable domain is fused to the Fc-knob domain with a hinge region and the same as the scFv of anti-CD300 to the Fc-hole domain, or vice versa. The Fab-Fc and scFv-Fc fragments can be paired via the interaction of the Fc regions. This BsAb canreduce eosinophil signaling, inhibit bronchoalveolar lavage fluid inflammation, eosinophil, mast cell mediator release and reverse lung inflammation. It is designed for the research of Asthma therapy.

Datasheet INQUIRY

Specifications

Targets

CCR3 & CD300

Type

Fab-Fc Fusion Proteins

Species Reactivity

Human

Application

FuncS; Promising therapeutic agent

Related Disease

Asthma

Targets

Target 1

CCR3

Gene ID

1232

UniProt ID

P51677

Alternative Names

CCR3; C-C motif chemokine receptor 3; CKR3; CD193; CMKBR3; CC-CKR-3

Target 2

CD300

Gene ID

11314

UniProt ID

Q9UGN4

Alternative Names

CD300A; CD300a molecule; IRC1; IRC2; CLM-8; IRp60; IGSF12; CMRF35H; CMRF-35H; CMRF35-H; CMRF35H9; CMRF35-H9; IRC1/IRC2; CMRF-35-H9

Our products and services are for research use only, and not for use in diagnostic or therapeutic procedures.

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Recombinant Anti-CCR3 x Anti-CD300 Bispecific Antibody (Fab-scFv-Fc) (CAT#: FABVC-028)

Specifications

Targets

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