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CCR3 & CD300 Bispecific Antibodies
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Product List

CAT# Product Name Species Reactivity BsAb Type Target 1 Host Animal 1 Target 2 Host Animal 2 INQUIRY
T-BSDB-H203 Recombinant Human Anti-CCR3 x Human Anti-CD300 Bispecific Antibody (Tandem Diabody) Human Tandem Diabody CCR3 Human CD300 Human Inquiry
T-BSDB-028 Recombinant Anti-CCR3 x Anti-CD300 Bispecific Antibody (Tandem Diabody) Human Tandem Diabody CCR3 Mouse CD300 Mouse Inquiry
SCIGG-H205 Recombinant Human Anti-CCR3 x Human Anti-CD300 Bispecific Antibody (scIgG) Human Single chain IgGs CCR3 Human CD300 Human Inquiry
SCIGG-028 Recombinant Anti-CCR3 x Anti-CD300 Bispecific Antibody (scIgG) Human Single chain IgGs CCR3 Mouse CD300 Mouse Inquiry
FVTIG-H205 Recombinant Human Anti-CCR3 x Human Anti-CD300 Bispecific Antibody (scFv4-Ig) Human scFv4-Ig CCR3 Human CD300 Human Inquiry
FVTIG-028 Recombinant Anti-CCR3 x Anti-CD300 Bispecific Antibody (scFv4-Ig) Human scFv4-Ig CCR3 Mouse CD300 Mouse Inquiry
BSSG-H205 Recombinant Human Anti-CCR3 x Human Anti-CD300 Bispecific Antibody (scFv-IgG) Human scFv-IgG CCR3 Human CD300 Human Inquiry
BSSG-028 Recombinant Anti-CCR3 x Anti-CD300 Bispecific Antibody (scFv-IgG) Human scFv-IgG CCR3 Mouse CD300 Mouse Inquiry
IGLFV-H205 Recombinant Human Anti-CCR3 x Human Anti-CD300 Bispecific Antibody (IgG(L)-scFv) Human IgG-scFv CCR3 Human CD300 Human Inquiry
IGLFV-028 Recombinant Anti-CCR3 x Anti-CD300 Bispecific Antibody (IgG(L)-scFv) Human IgG-scFv CCR3 Mouse CD300 Mouse Inquiry
BSGV-H205 Recombinant Human Anti-CCR3 x Human Anti-CD300 Bispecific Antibody (IgG-Fv) Human IgG-Fv CCR3 Mouse CD300 Mouse Inquiry
BSGV-028 Recombinant Anti-CCR3 x Anti-CD300 Bispecific Antibody (IgG-Fv) Human IgG-Fv CCR3 Mouse CD300 Mouse Inquiry
BSDG-H205 Recombinant Human Anti-CCR3 x Human Anti-CD300 Bispecific Antibody (Fv-IgG) Human Fv-IgG CCR3 Human CD300 Human Inquiry
BSDG-028 Recombinant Anti-CCR3 x Anti-CD300 Bispecific Antibody (Fv-IgG) Human Fv-IgG CCR3 Mouse CD300 Mouse Inquiry
BABFV-H205 Recombinant Human Anti-CCR3 x Human Anti-CD300 Bispecific Antibody (F(ab')2-scFv2) Human F(ab')2-scFv2 CCR3 Human CD300 Human Inquiry
BABFV-028 Recombinant Anti-CCR3 x Anti-CD300 Bispecific Antibody (F(ab')2-scFv2) Human F(ab')2-scFv2 CCR3 Mouse CD300 Mouse Inquiry
FABVC-H205 Recombinant Human Anti-CCR3 x Human Anti-CD300 Bispecific Antibody (Fab-scFv-Fc) Human Fab-scFv/sdAb-Fc CCR3 Human CD300 Human Inquiry
FABVC-028 Recombinant Anti-CCR3 x Anti-CD300 Bispecific Antibody (Fab-scFv-Fc) Human Fab-scFv/sdAb-Fc CCR3 Mouse CD300 Mouse Inquiry
SCDBC-H205 Recombinant Human Anti-CCR3 x Human Anti-CD300 Bispecific Antibody (scDiabody-CH3) Human scDiabody-CH3 CCR3 Human CD300 Human Inquiry
SCDBC-028 Recombinant Anti-CCR3 x Anti-CD300 Bispecific Antibody (scDiabody-CH3) Human scDiabody-CH3 CCR3 Mouse CD300 Mouse Inquiry
BSDBC-H205 Recombinant Human Anti-CCR3 x Human Anti-CD300 Bispecific Antibody (Diabody-CH3) Human Diabody-CH3 CCR3 Human CD300 Human Inquiry
BSDBC-028 Recombinant Anti-CCR3 x Anti-CD300 Bispecific Antibody (Diabody-CH3) Human Diabody-CH3 CCR3 Mouse CD300 Mouse Inquiry
SCDBF-H205 Recombinant Human Anti-CCR3 x Human Anti-CD300 Bispecific Antibody (scDiabody-Fc) Human scDiabody-Fc CCR3 Human CD300 Human Inquiry
SCDBF-028 Recombinant Anti-CCR3 x Anti-CD300 Bispecific Antibody (scDiabody-Fc) Human scDiabody-Fc CCR3 Mouse CD300 Mouse Inquiry
BSFVF-H205 Recombinant Human Anti-CCR3 x Human Anti-CD300 Bispecific Antibody (Tandem scFv-Fc) Human Tandem scFv-Fc CCR3 Human CD300 Human Inquiry
BSFVF-028 Recombinant Anti-CCR3 x Anti-CD300 Bispecific Antibody (Tandem scFv-Fc) Human Tandem scFv-Fc CCR3 Mouse CD300 Mouse Inquiry
BSDBF-H205 Recombinant Human Anti-CCR3 x Human Anti-CD300 Bispecific Antibody (Diabody-Fc) Human Diabody-Fc CCR3 Human CD300 Human Inquiry
BSDBF-028 Recombinant Anti-CCR3 x Anti-CD300 Bispecific Antibody (Diabody-Fc) Human Diabody-Fc CCR3 Mouse CD300 Mouse Inquiry
BSTF-H205 Recombinant Human Anti-CCR3 x Human Anti-CD300 Bispecific Antibody (scFv-Fc-scFv) Human scFv-Fc-scFv CCR3 Mouse CD300 Mouse Inquiry
BSTF-028 Recombinant Anti-CCR3 x Anti-CD300 Bispecific Antibody (scFv-Fc-scFv) Human scFv-Fc-scFv CCR3 Mouse CD300 Mouse Inquiry
BSCFV-H205 Recombinant Human Anti-CCR3 x Human Anti-CD300 Bispecific Antibody (scFv-Fc) Human scFv-Fc CCR3 Mouse CD300 Mouse Inquiry
BSCFV-028 Recombinant Anti-CCR3 x Anti-CD300 Bispecific Antibody (scFv-Fc) Human scFv-Fc CCR3 Mouse CD300 Mouse Inquiry
MNAB-H205 Recombinant Human Anti-CCR3 x Human Anti-CD300 Bispecific Antibody (Miniantibody) Human Miniantibody CCR3 Mouse CD300 Mouse Inquiry
MNAB-028 Recombinant Anti-CCR3 x Anti-CD300 Bispecific Antibody (Miniantibody) Human Miniantibody CCR3 Mouse CD300 Mouse Inquiry
BSFC-H205 Recombinant Human Anti-CCR3 x Human Anti-CD300 Bispecific Antibody (scFv-CH3) Human scFv-CH3 CCR3 Mouse CD300 Mouse Inquiry
BSFC-028 Recombinant Anti-CCR3 x Anti-CD300 Bispecific Antibody (scFv-CH3) Human scFv-CH3 CCR3 Mouse CD300 Mouse Inquiry
BSCC-H205 Recombinant Human Anti-CCR3 x Human Anti-CD300 Bispecific Antibody (scFv-CH1/CL) Human scFv-CH1/CL CCR3 Mouse CD300 Mouse Inquiry
BSCC-028 Recombinant Anti-CCR3 x Anti-CD300 Bispecific Antibody (scFv-CH1/CL) Human scFv-CH1/CL CCR3 Mouse CD300 Mouse Inquiry
BIBD-H205 Recombinant Human Anti-CCR3 x Human Anti-CD300 Bispecific Antibody (Bibody) Human Bibody CCR3 Mouse CD300 Mouse Inquiry
BIBD-028 Recombinant Anti-CCR3 x Anti-CD300 Bispecific Antibody (Bibody) Human Bibody CCR3 Mouse CD300 Mouse Inquiry
FABFV-H205 Recombinant Human Anti-CCR3 x Human Anti-CD300 Bispecific Antibody (Fab-Fv) Human Fab-Fv CCR3 Human CD300 Human Inquiry
FABFV-028 Recombinant Anti-CCR3 x Anti-CD300 Bispecific Antibody (Fab-Fv) Human Fab-Fv CCR3 Mouse CD300 Mouse Inquiry
MiniB-H205 Recombinant Human Anti-CCR3 x Human Anti-CD300 Bispecific Antibody (Minibody) Human Minibody CCR3 Human CD300 Human Inquiry
MiniB-028 Recombinant Anti-CCR3 x Anti-CD300 Bispecific Antibody (Minibody) Human Minibody CCR3 Mouse CD300 Mouse Inquiry
SCDB-H203 Recombinant Human Anti-CCR3 x Anti-CD300 Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody CCR3 Human CD300 Human Inquiry
FABIG-H203 Recombinant Human Anti-CCR3 x Anti-CD300 Bispecific Antibody (Fab-IgG) Human Fab-IgG CCR3 Human CD300 Human Inquiry
TRIB-H205 Recombinant Human Anti-CCR3 x Anti-CD300 Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv CCR3 Human CD300 Human Inquiry
BSIG-H203 Human Anti-CCR3 x Anti-CD300 Bispecific Antibody (IgG-IgG) Human IgG-IgG CCR3 Human CD300 Human Inquiry
CROSSAB-H203 Recombinant Human Anti-CCR3 x Anti-CD300 Bispecific Antibody (CrossMab) Human CrossMab CCR3 Human CD300 Human Inquiry
IGFV-H203 Recombinant Human Anti-CCR3 x Anti-CD300 Bispecific Antibody (IgG-scFv) Human IgG-scFv CCR3 Human CD300 Human Inquiry
BSDB-H203 Recombinant Human Anti-CCR3 x Anti-CD300 Bispecific Antibody (Diabody) Human Diabody CCR3 Human CD300 Human Inquiry
BSFAB-H203 Recombinant Human Anti-CCR3 x Anti-CD300 Bispecific Antibody (Tandem Fab) Human Tandem Fab CCR3 Human CD300 Human Inquiry
BSFV-H203 Recombinant Human Anti-CCR3 x Anti-CD300 Bispecific Antibody (Tandem scFv) Human Tandem scFv CCR3 Human CD300 Human Inquiry
SCDB-028 Recombinant Anti-CCR3 x Anti-CD300 Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody CCR3 Mouse CD300 Mouse Inquiry
FABIG-028 Recombinant Anti-CCR3 x Anti-CD300 Bispecific Antibody (Fab-IgG) Human Fab-IgG CCR3 Mouse CD300 Mouse Inquiry
TRIB-028 Recombinant Anti-CCR3 x Anti-CD300 Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv CCR3 Mouse CD300 Mouse Inquiry
BSIG-028 Anti-CCR3 x Anti-CD300 Bispecific Antibody (IgG-IgG) Human IgG-IgG CCR3 Mouse CD300 Mouse Inquiry
CROSSAB-028 Recombinant Anti-CCR3 x Anti-CD300 Bispecific Antibody (CrossMab) Human CrossMab CCR3 Mouse CD300 Mouse Inquiry
IGFV-028 Recombinant Anti-CCR3 x Anti-CD300 Bispecific Antibody (IgG-scFv) Human IgG-scFv CCR3 Mouse CD300 Mouse Inquiry
BSDB-028 Recombinant Anti-CCR3 x Anti-CD300 Bispecific Antibody (Diabody) Human Diabody CCR3 Mouse CD300 Mouse Inquiry
BSFAB-028 Recombinant Anti-CCR3 x Anti-CD300 Bispecific Antibody (Tandem Fab) Human Tandem Fab CCR3 Mouse CD300 Mouse Inquiry
BSFV-028 Recombinant Anti-CCR3 x Anti-CD300 Bispecific Antibody (Tandem scFv) Human Tandem scFv CCR3 Mouse CD300 Mouse Inquiry

Background

CCR3, a chemokine receptor, binds and responds to various chemokines, while CD300, also a receptor, primarily functions in downregulating degranulation in mast cells and cytolytic activity in NK cells. The proven efficacy of the bispecific antibody targeting CCR3 and CD300 is demonstrated by its ability to inhibit eosinophils and mast cell activation, mediator release, and tissue remodeling in a murine model of chronic experimental asthma. Additionally, it effectively inhibits bronchoalveolar lavage fluid inflammation and reverses lung inflammation. This underscores the potential of a CCR3 and CD300 bispecific antibody as a powerful therapeutic tool for addressing tissue remodeling and airway inflammation.

CD300f and CCR3 signaling pathway. (Rozenberg, et al., 2018) Fig.1 CD300f regulates crucial signaling checkpoint CCR3 in eosinophils.1

Reference

  1. Rozenberg, Perri, et al. "CD300 family receptors regulate eosinophil survival, chemotaxis, and effector functions." Journal of Leukocyte Biology 104.1 (2018): 21-29.
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