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Recombinant Human Anti-CCR3 x Human Anti-CD300 Bispecific Antibody (scFv-Fc)  (CAT#: BSCFV-H205)

Recombinant Anti-CCR3 x Anti-CD300 Bispecific Antibody (scFv-Fc) is formed by fusing two different scFv fragments to the hinge and Fc regions, in which the Fc region are engineered by KIH. Two of scFv moiety has the antibody variable domain of either anti-CCR3 specificity or anti-CD300 specificity, which produces bivalent IgG-like molecules with desired characteristics of intact antibodies. This BsAb canreduce eosinophil signaling, inhibit bronchoalveolar lavage fluid inflammation, eosinophil, mast cell mediator release and reverse lung inflammation. It is designed for the research of Asthma therapy.
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Specifications

Targets
CCR3 & CD300
Type
scFv-based Bispecific Fragments
Species Reactivity
Human
Application
FuncS; Promising therapeutic agent
Related Disease
Asthma

Targets

Target 1
CCR3
Gene ID
UniProt ID
Alternative Names
CCR3; C-C motif chemokine receptor 3; CKR3; CD193; CMKBR3; CC-CKR-3
Target 2
CD300
Gene ID
UniProt ID
Alternative Names
CD300A; CD300a molecule; IRC1; IRC2; CLM-8; IRp60; IGSF12; CMRF35H; CMRF-35H; CMRF35-H; CMRF35H9; CMRF35-H9; IRC1/IRC2; CMRF-35-H9
Our products and services are for research use only, and not for use in diagnostic or therapeutic procedures.
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