Home > Products > CCR3 & CD300 > Recombinant Human Anti-CCR3 x Human Anti-CD300 Bispecific Antibody (Fab-scFv-Fc)

Recombinant Human Anti-CCR3 x Human Anti-CD300 Bispecific Antibody (Fab-scFv-Fc)  (FABVC-H205)

Recombinant Anti-CCR3 x Anti-CD300 Bispecific Antibody (Fab-scFv-Fc) requires expression of three polypeptide chains, encoding two heavy chains (Fc-containing chains) and one light chain, respectively. The Fab of anti-CCR3 antibody variable domain is fused to the Fc-knob domain with a hinge region and the same as the scFv of anti-CD300 to the Fc-hole domain, or vice versa. The Fab-Fc and scFv-Fc fragments can be paired via the interaction of the Fc regions. This BsAb canreduce eosinophil signaling, inhibit bronchoalveolar lavage fluid inflammation, eosinophil, mast cell mediator release and reverse lung inflammation. It is designed for the research of Asthma therapy.

Specifications
Targets
CCR3 & CD300
Type
Fab-Fc Fusion Proteins
Species Reactivity
Human
Target 1
CCR3
Host Animal 1
Human
Target 2
CD300
Host Animal 2
Human
Application
FuncS; Promising therapeutic agent
Related Disease
Asthma
Targets
Target 1
CCR3
Gene ID
UniProt ID
Alternative Names
CCR3; C-C motif chemokine receptor 3; CKR3; CD193; CMKBR3; CC-CKR-3
Target 2
CD300
Gene ID
UniProt ID
Alternative Names
CD300A; CD300a molecule; IRC1; IRC2; CLM-8; IRp60; IGSF12; CMRF35H; CMRF-35H; CMRF35-H; CMRF35H9; CMRF35-H9; IRC1/IRC2; CMRF-35-H9
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